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Literature summary for 3.4.21.37 extracted from

  • Sonawane, A.; Jyot, J.; During, R.; Ramphal, R.
    Neutrophil elastase an innate immunity effector molecule represses flagellin transcription in Pseudomonas aeruginosa (2006), Infect. Immun., 74, 6682 - 6689.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is more active in the mucus environment, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Na+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens neutrophil elastase, a component of the innate host defense system, is bactericidal for Gram-negative bacteria and degrades bacterial virulence factors, resistance of Pseudomonas aeruginosa to the bactericidal effect of neutrophil elastase, as well as this organism’s ability to sense this enzyme’s presence and downregulate the synthesis of a pathogen-associated molecular pattern, may be the key factors in allowing Pseudomonas aeruginosa to colonize the lungs, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-
neutrophil
-
Homo sapiens
-
respiratory mucus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neutrophil elastase, a component of the innate host defense system, is bactericidal for Gram-negative bacteria and degrades bacterial virulence factors, resistance of Pseudomonas aeruginosa to the bactericidal effect of neutrophil elastase, as well as this organism’s ability to sense this enzyme’s presence and downregulate the synthesis of a pathogen-associated molecular pattern, may be the key factors in allowing Pseudomonas aeruginosa to colonize the lungs, overview Homo sapiens ?
-
?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens