Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-Formyl-Met-Leu-Phe | a chemotactic peptide, stimulates the enzyme and its release from primary granules of PMN | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone | specific inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
primary granule | primary, of PMN | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Na+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
annexin 1 + H2O | Homo sapiens | annexin 1 is externalized and truncated upon adhesion of polymorphonuclear leukocytes to endothelial cells, annexin 1 participates in regulating leukocyte emigration into inflamed tissue through N-terminal peptides generated at inflammatory sites, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
polymorphonuclear leukocyte | i.e. PMN | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
annexin 1 + H2O | annexin 1 is externalized and truncated upon adhesion of polymorphonuclear leukocytes to endothelial cells, annexin 1 participates in regulating leukocyte emigration into inflamed tissue through N-terminal peptides generated at inflammatory sites, overview | Homo sapiens | ? | - |
? | |
annexin 1 + H2O | cleavage of N-terminal peptides, recombinant substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HLE | - |
Homo sapiens |
leukocyte elastase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |