Literature summary for 3.4.21.37 extracted from

Maffia, P.C.; Zittermann, S.E.; Scimone, M.L.; Tateosian, N.; Amiano, N.; Guerrieri, D.; Lutzky, V.; Rosso, D.; Romeo, H.E.; Garcia, V.E.; Issekutz, A.C.; Chuluyan, H.E.
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability (2007), Am. J. Pathol., 171, 928-937.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability, elastase induces IkappaBalpha degradation in dendritic cells, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	healthy individuals and patients with cyclic neutropenia	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-
polymorphonuclear leukocyte	i.e. PMN	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability, elastase induces IkappaBalpha degradation in dendritic cells, overview	Homo sapiens	?	-	?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Homo sapiens	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)