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Literature summary for 3.4.21.37 extracted from

  • Doring, G.; Frank, F.; Boudier, C.; Herbert, S.; Fleischer, B.; Bellon, G.
    Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis (1995), J. Immunol., 154, 4842-4850.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
x * 29000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, enzyme is assumed to play a key role in the gradual decrease of lung function during cystic fibrosis ? protein cleaved at at least one location ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with cystic fibrosis
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte polymorphonuclear leukocytes Homo sapiens
-
lung
-
Homo sapiens
-
sputum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD2 + H2O CD2 on peripheral blood T lymphocytes Homo sapiens ?
-
?
CD4 + H2O CD4 on peripheral blood T lymphocytes Homo sapiens ?
-
?
CD8 + H2O CD8 on peripheral blood T lymphocytes Homo sapiens ?
-
?
Elastin + H2O
-
Homo sapiens ?
-
?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, enzyme is assumed to play a key role in the gradual decrease of lung function during cystic fibrosis Homo sapiens ? protein cleaved at at least one location ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
? x * 29000, SDS-PAGE Homo sapiens