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Literature summary for 3.4.21.37 extracted from

  • Jones, A.; Elphick, H.; Pettitt, E.; Everard, M.L.; Evans, G.S.
    Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase (2002), Eur. Respir. J., 19, 1136-1141.
    View publication on PubMed
Search for more literature for 3.4.21.37

Activating Compound

Activating Compound Comment Organism Structure
colistin significant stimulation of purified elastase and elastase activity in sputum samples, able to reverse inhibition by heparin Homo sapiens
erythromycin significant stimulation of purified elastase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin very potent inhibitor, complete inhibition at nanomolar concentrations, colistin is unable to reverse inhibition Homo sapiens
ceftazidime slight inhibition of purified elastase Homo sapiens
gentamycin slight inhibition of purified elastase Homo sapiens
heparin strong inhibition, partly reversible by addition of colistin Homo sapiens
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone complete inhibition at low micromolar concentrations, colistin is unable to reverse the complete inhibition with 0.005 mM but able to reverse the partial inhibition with 0.0005 mM N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone Homo sapiens
tobramycin slight inhibition of purified elastase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged ? protein cleaved at at least one location ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with cystic fibrosis
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-
sputum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged Homo sapiens ? protein cleaved at at least one location ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?