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Literature summary for 3.4.21.37 extracted from
- Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor (1996), Am. J. Respir. Cell Mol. Biol., 15, 283-291.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alginate | weak inhibition, elastase molecule interacts with 19 uronic acid units of alginate | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Homo sapiens | ? | protein cleaved at at least one location | ? | |
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