Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.37 extracted from

  • Navia, M.A.; McKeever, B.M.; Springer, J.P.; Lin, T.Y.; Williams, H.R.; Fluder, E.M.; Dorn, C.P.; Hoogsteen, K.
    Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution (1989), Proc. Natl. Acad. Sci. USA, 86, 7-11.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
complex of the enzyme with methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone. The asymmetric distribution of positively charged residues on the surface of the enzyme suggests a mechanism for the specific incorporation of the enzyme into primary granules in the neutrophil Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methoxysuccinyl-Ala-Ala-Pro-Val-CH2Cl
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08246
-
-