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Literature summary for 3.4.21.37 extracted from

  • Wei, A.Z.; Mayr, I.; Bode, W.
    The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor (1988), FEBS Lett., 234, 367-373.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
ammonium sulfate precipitation, 2.3 A crystal structure of leukocyte elastase in a complex with methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
human pancreatic secretory trypsin inhibitor variants optimized with respect to the affinity and specificity for human leukocyte elastase relative to trypsin, and in particular chymotrypsin Homo sapiens
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08246
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki-values for variants of human pancreatic secretory trypsin inhibitor optimized with respect to the affinity and specificity for human leukocyte elastase relative to trypsin, and in particular chymotrypsin Homo sapiens