Application | Comment | Organism |
---|---|---|
medicine | imbalance between elastase and its endogenous inhibitors may result in several pathophysiological states such as chronic obstructive pulmonary disease, asthma, emphysema, cystic fibrosis and chronic inflammatory diseases. An orally active leukocyte elastase can be useful for the treatment of these diseases. SSR69071 is a selective, orally active, and potent inhibitor of leukocyte elastase with good penetration in respiratory tissues | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SSR69071 | i.e. 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3-one-1,1-dioxide, a selective, orally active, and potent inhibitor of leukocyte elastase with good penetration in respiratory tissues | Homo sapiens | |
SSR69071 | - |
Mus musculus | |
SSR69071 | - |
Oryctolagus cuniculus | |
SSR69071 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | imbalance between elastase and its endogenous inhibitors may result in several pathophysiological states such as chronic obstructive pulmonary disease, asthma, emphysema, cystic fibrosis and chronic inflammatory diseases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sputum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | imbalance between elastase and its endogenous inhibitors may result in several pathophysiological states such as chronic obstructive pulmonary disease, asthma, emphysema, cystic fibrosis and chronic inflammatory diseases | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000000168 | - |
SSR69071 | pH 7.8 | Homo sapiens | |
0.00000168 | - |
SSR69071 | pH 7.8 | Mus musculus | |
0.00000301 | - |
SSR69071 | pH 7.8 | Rattus norvegicus | |
0.000005571 | - |
ZD8321 | pH 7.8 | Homo sapiens | |
0.00003475 | - |
ZD8321 | pH 7.8 | Mus musculus | |
0.000058 | - |
SSR69071 | pH 7.8 | Oryctolagus cuniculus | |
0.00006 | - |
ZD8321 | pH 7.8 | Rattus norvegicus | |
0.000139 | - |
ZD8321 | pH 7.8 | Oryctolagus cuniculus |