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Literature summary for 3.4.21.37 extracted from
- The neutral proteases of human granulocytes. Isolation and partial characterization of granulocyte elastases (1974), Eur. J. Biochem., 42, 519-527.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha1-antitrypsin | - |
Homo sapiens | |
| alpha2-Macroglobulin | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | lysosome-like granule | Homo sapiens | 5764 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| granulocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Elastin + H2O | - |
Homo sapiens | ? | - |
? |  |
| Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | three proteins with a slight difference in electrophoretic mobility: 33000 Da, 34000 Da and 36500 Da are detected by SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
digestion of elastin | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | pH 6.0: about 50% of maximal activity, pH 9.0: about 95% of maximal activity | Homo sapiens |
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Release 2023.1 (January 2023)
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