Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
KLK1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose in human proximal tubular epithelial cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | molecular knockdown of endogenous KLK1 expression attenuates advanced glycation end-products-induced interleukin-8 and intercellular adhesion molecule-1 productions in vitro | Homo sapiens |
physiological function | up-regulation of KLK1 in tubular epithelial cells may mediate pro-inflammatory pathway and protease-activated receptor activation during diabetic nephropathy | Homo sapiens |