Literature summary for 3.4.21.35 extracted from

Youcef, G.; Belaidi, E.; Waeckel, L.; Fazal, L.; Clemessy, M.; Vincent, M.P.; Zadigue, G.; Richer, C.; Alhenc-Gelas, F.; Ovize, M.; Pizard, A.
Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse (2015), Biochem. Pharmacol., 94, 22-29.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-2266 + H2O	i.e. H-D-Val-Leu-Arg-4-nitroanilide	Mus musculus	?	-	?

General Information

General Information	Comment	Organism
malfunction	partial or total deficiency in tissue kallikrein induces resistance to the infarct size reducing effect of cyclosporin A in cardiac ischemia in mice	Mus musculus
physiological function	tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse. The enzyme is required for the mitochondrial action of cyclosporin A and may interact with cyclophilin D	Mus musculus

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Release 2023.1 (January 2023)