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Literature summary for 3.4.21.35 extracted from
- Modifications in tissue kallikrein activity with indomethacin and prednisolone treatment in arthritic rats (2010), Inflammopharmacology, 18, 113-117.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| paw | - |
Rattus norvegicus | - |
| synovial tissue | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Val-Leu-Arg-4-nitroanilide + H2O | S-2266, selective tissue kallikrein substrate | Rattus norvegicus | D-Val-Leu-Arg + 4-nitroaniline | - |
? |  |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | prednisolone treatment for 9 days to adjuvant arthritic rats results in reduction in the mean synovial tissue kallikrein level as compared to the non-treated arthritic rats | down |
| Rattus norvegicus | indomethacin-treated rats show elevated mean paw tissue kallikrein level as compared with the non-treated arthritic rats. Prednisolone treatment for 9 days to adjuvant arthritic rats results in appreciable raise in the mean paw tissue level as compared to the non-treated arthritic rats. Indomethacin-treated rats also show elevated mean paw tissue kallikrein level as compared to the non-treated arthritic rats | up |
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