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Literature summary for 3.4.21.35 extracted from
- Role of tissue kallikrein in regulation of tubule function (2011), Curr. Opin. Nephrol. Hypertens., 20, 523-528.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| connecting tubule cell | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | tissue kallkrein deficient mice exhibit net transepithelial potassium absorption in cortical collecting ducts because of abnormal activation of the colonic H+,K+-ATPase in intercalated cells and reduced potassium secretion by principal cells secondary to decreased epithelial sodium channel activity | Mus musculus |
| physiological function | tissue kallikrein acts directly on epithelial sodium channel in order to modulate its activity but is not critical for the regulation of renal sodium homeostasis. Tissue kallikrein is a kaliuretic factor that provides a rapid abd aldosterone-independent protection against hyperkalemia after a dietary potassium load | Mus musculus |
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Release 2023.1 (January 2023)
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