Application | Comment | Organism |
---|---|---|
drug development | recombinant adeno-associated virus-mediated tissue kallikrein gene delivery has multiple therapeutic possibilities for treating hypertension, not only by decreasing blood pressure, but also by directly inhibiting end-organ damage | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
860-bp fragment of tissue kallikrein containing an open reading frame subcloned into pXXUF1 downstream of CMV. recombinant adeno-associated virus encoding tissue kallikrein delivered to spontaneously hypertensive rats and cultured HEK-293 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
tissue kallikrein | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | treatment with recombinant adeno-associated virus-tissue kallikrein decreases cell apoptosis in the target organs of spontaneous hypertensive rats and also inhibits lipopolysaccharide-induced HEK-293 apoptosis. The recombinant adeno-associated virus-tissue kallikrein delivery system increases the levels of apoptosis-inhibiting proteins bcl-2 and bcl-x(L), and decreases the level of Bax and the activity of caspase 3, two promoters of apoptosis. In addition to its role in the inhibition of apoptosis, adeno-associated virus-tissue kallikrein activates the cell survival and proliferation signaling pathways ERK1/2 and PI3K/AKT | Homo sapiens |