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Literature summary for 3.4.21.35 extracted from

  • Prassas, I.; Paliouras, M.; Datti, A.; Diamandis, E.P.
    High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies (2008), Clin. Cancer Res., 14, 5778-5784.
    View publication on PubMed
Search for more literature for 3.4.21.35

Inhibitors

Inhibitors Comment Organism Structure
convallatoxin
-
 Homo sapiens
digitoxigenin
-
 Homo sapiens
digitoxin
-
 Homo sapiens
digoxin
-
 Homo sapiens
additional information cardiac glycosides can dramatically suppress the transcription of KLKs Homo sapiens
Ouabain
-
 Homo sapiens
peruvoside
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-468 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
KLK5
-
 Homo sapiens
KLK6
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000006
-
 KLK6 Homo sapiens peruvoside
0.000008
-
 KLK5 Homo sapiens peruvoside
0.000042
-
 KLK5 Homo sapiens digitoxin
0.00005
-
 KLK6 Homo sapiens digitoxin
0.000065
-
 KLK6 Homo sapiens Ouabain
0.00009
-
 KLK5 Homo sapiens digoxin
0.0001
-
 KLK6 Homo sapiens digoxin
0.00012
-
 KLK5 Homo sapiens Ouabain
0.00013
-
 KLK6 Homo sapiens convallatoxin
0.00015
-
 KLK5 Homo sapiens convallatoxin
0.00021
-
 KLK5 Homo sapiens digitoxigenin
0.00038
-
 KLK6 Homo sapiens digitoxigenin