Literature summary for 3.4.21.35 extracted from

Cloutier, S.M.; Kuendig, C.; Felber, L.M.; Fattah, O.M.; Chagas, J.R.; Gygi, C.M.; Jichlinski, P.; Leisinger, H.J.; Deperthes, D.
Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates (2004), Eur. J. Biochem., 271, 607-613.

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Inhibitors

Inhibitors	Comment	Organism	Structure
recombinant alpha1-antichymotrypsin	generation of selective inhibitors based on substrates selected from a pentapeptide phage-display library and transplanted to the reactive-site loop of alpha1-antichymotrypsin. Engineered alpha1-antichymotrypsins with peptides RGR-SE and ER-VSP are inhibitory and specific to enzyme.	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.067	-	Z-L-Phe-L-Arg-7-amido-4-methylcoumarin	pH 7.5, 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)