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Literature summary for 3.4.21.35 extracted from
- Bronchial tissue kallikrein activity is regulated by hyaluronic acid binding (1999), Am. J. Respir. Cell Mol. Biol., 21, 666-674.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| chymase | stimulation, in correlation with secretory leukoprotease inhibitor stimulation, in stimulated serous cells | Ovis aries | |
| hyaluronidase | increases K2 enzyme activity by digesting the K2-bound hyaluronic acid | Ovis aries |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hyaluronic acid | binds to the enzyme in vivo | Ovis aries |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secretion by serous cells | Ovis aries | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Ovis aries | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | primary, tracheal submucosal gland | Ovis aries | - |
| mucous gland | tracheal, primary cell culture | Ovis aries | - |
| serous gland | - |
Ovis aries | - |
| trachea | submucosal gland, primary cell culture | Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Val-Leu-Arg-p-nitroanilide + H2O | - |
Ovis aries | D-Val-Leu-Arg + p-nitroaniline | - |
? | |
| kininogen + H2O | high-molecular weight kininogen | Ovis aries | bradykinin + kinin heavy chain + kinin light chain | - |
? | |
| kininogen + H2O | 3 additional cleavage sites at Arg427, Arg437, and Arg457 | Ovis aries | bradykinin + kinin heavy chain + kinin light chain | - |
? | |
| polypeptide + H2O | - |
Ovis aries | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TK | - |
Ovis aries |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.2 | - |
assay at | Ovis aries |
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Release 2023.1 (January 2023)
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