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Literature summary for 3.4.21.34 extracted from

  • Van der Graaf, F.; Tans, G.; Bouma, B.N.; Griffin, J.H.
    Isolation and functional properties of the heavy and light chains of human plasma kallikrein (1982), J. Biol. Chem., 257, 14300-14305.
    View publication on PubMed
Search for more literature for 3.4.21.34

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
 1 * 43000, 1 * 33000, SDS-PAGE Homo sapiens
43000
-
 1 * 43000, 1 * 33000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kininogen + H2O Homo sapiens cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 kallikrein I, kallikrein II
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kininogen + H2O cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation Homo sapiens ?
-
 ?
kininogen + H2O cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin Homo sapiens bradykinin + ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 43000, 1 * 33000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens