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Literature summary for 3.4.21.34 extracted from

  • Goebel, K.; Asaridou, C.M.; Merker, M.; Eichler, S.; Herrmann, A.M.; Geuss, E.; Ruck, T.; Schuengel, L.; Groeneweg, L.; Narayanan, V.; Schneider-Hohendorf, T.; Gross, C.C.; Wiendl, H.; Kehrel, B.E.; Kleinschnitz, C.; Meuth, S.G.
    Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release (2019), Proc. Natl. Acad. Sci. USA, 116, 271-276 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Activating Compound

Activating Compound Comment Organism Structure
factor XIIa
-
 Mus musculus
factor XIIa
-
 Homo sapiens

Application

Application Comment Organism
medicine enzyme inhibition can decrease blood-brain barrier damage and cell invasion during neuroinflammation and may offer a strategy for the treatment of multiple sclerosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XII + H2O Mus musculus
-
 activated factor XII
-
 ?
factor XII + H2O Homo sapiens
-
 activated factor XII
-
 ?
kininogen + H2O Mus musculus
-
 bradykinin + fragments of kininogen
-
 ?
kininogen + H2O Homo sapiens
-
 bradykinin + fragments of kininogen
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XII + H2O
-
 Mus musculus activated factor XII
-
 ?
factor XII + H2O
-
 Homo sapiens activated factor XII
-
 ?
kininogen + H2O
-
 Mus musculus bradykinin + fragments of kininogen
-
 ?
kininogen + H2O
-
 Homo sapiens bradykinin + fragments of kininogen
-
 ?

Expression

Organism Comment Expression
Homo sapiens enzyme levels are markedly enhanced in active central nervous system lesions of multiple sclerosis patients up

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to decreased immune cell trafficking in the course of neuroinflammation Mus musculus
malfunction enzyme deficiency leads to decreased immune cell trafficking in the course of neuroinflammation Homo sapiens
physiological function the enzyme modulates endothelial cell function in a protease-activated receptor-2-dependent manner, leading to an up-regulation of the cellular adhesion molecules intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, thereby amplifying leukocyte trafficking. The enzyme is an important direct regulator of blood-brain barrier integrity Mus musculus
physiological function the enzyme modulates endothelial cell function in a protease-activated receptor-2-dependent manner, leading to an up-regulation of the cellular adhesion molecules intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, thereby amplifying leukocyte trafficking. The enzyme is an important direct regulator of blood-brain barrier integrity Homo sapiens