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Literature summary for 3.4.21.34 extracted from
- Modulation of the plasma kallikrein-kinin system proteins performed by heparan sulfate proteoglycans (2017), Front. Physiol., 8, 481 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| high molecular weight kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| high molecular weight kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-KAL | - |
Homo sapiens |
| Kal | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a central role in a variety of proteolytic systems, such as the intrinsic pathway of coagulation, the plasma kallikrein-kinin system, the fibrinolysis pathway, the renin-angiotensin system, and the complement pathways. Therefore, it is an important regulator in the pathogenesis of thrombosis, inflammation, and blood pressure | Homo sapiens |
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Release 2023.1 (January 2023)
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