Literature summary for 3.4.21.34 extracted from

Xu, M.; Chen, Y.; Xu, P.; Andreasen, P.A.; Jiang, L.; Li, J.; Huang, M.
Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 (2018), FEBS Lett., 592, 2658-2667 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Pichia pastoris strain, X-33	Mus musculus

Crystallization (Commentary)

Crystallization (Comment)	Organism
apoenzyme and in complex with mupain-1-16, sitting drop vapor diffusion method, using 25% (w/v) poly(ethylene glycol) 3350, 0.1 M Tris-HCl pH8.5, 0.1 M NaCl	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
mupain-1-16	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kininogen + H2O	Mus musculus	-	bradykinin + fragments of kininogen	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P26262	-	-

Purification (Commentary)

Purification (Comment)	Organism
SP Sepharose column chromatography and Superdex 75 gel filtration	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
kininogen + H2O	-	Mus musculus	bradykinin + fragments of kininogen	-	?

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Release 2023.1 (January 2023)