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Literature summary for 3.4.21.34 extracted from

  • Fischer, C.; Lamer, T.; Wang, W.; McKinnie, S.M.K.; Iturrioz, X.; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C.
    Plasma kallikrein cleaves and inactivates apelin-17 Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents (2019), Eur. J. Med. Chem., 166, 119-124 .
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.097
-
 apelin-17 at pH 7.4 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XII + H2O Homo sapiens
-
 activated factor XII + ?
-
 ?
kininogen + H2O Homo sapiens
-
 bradykinin + fragments of kininogen
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apelin-17 + H2O the enzyme cleaves the first three N-terminal amino acids (KFR) of apelin-17 Homo sapiens KFR + ?
-
 ?
factor XII + H2O
-
 Homo sapiens activated factor XII + ?
-
 ?
kininogen + H2O
-
 Homo sapiens bradykinin + fragments of kininogen
-
 ?

Synonyms

Synonyms Comment Organism
KLKb1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
13.7
-
 apelin-17 at pH 7.4 and 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
140
-
 apelin-17 at pH 7.4 and 37°C Homo sapiens