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Literature summary for 3.4.21.34 extracted from

  • Ottaiano, T.F.; Andrade, S.S.; de Oliveira, C.; Silva, M.C.C.; Buri, M.V.; Juliano, M.A.; Girao, M.J.B.C.; Sampaio, M.U.; Schmaier, A.H.; Wlodawer, A.; Maffei, F.H.A.; Oliva, M.L.V.
    Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP (2017), Biochimie, 135, 72-81 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
factor XIIa
-
Homo sapiens
prolylcarboxypeptidase
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
high molecular weight kininogen + H2O Homo sapiens
-
bradykinin + fragments of kininogen
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens D-Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
?
high molecular weight kininogen + H2O
-
Homo sapiens bradykinin + fragments of kininogen
-
?

Subunits

Subunits Comment Organism
? x * 86000-88000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Plasma prekallikrein precursor Homo sapiens
PPK precursor Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme sensitizes human platelets by binding to platelet integrins through its KGD (Lys488-Gly489-Asp490 and Lys556-Gly557-Asp558) and KGE (Lys509-Gly510-Glu511) motifs and to cleave PAR-1. These actions enhance platelet activation by subthreshold doses of ADP leading to Ca2+ mobilization, MAPK-related signaling, and ATP release Homo sapiens