Literature summary for 3.4.21.34 extracted from

Varano Della Vergiliana, J.F.; Lansley, S.; Tan, A.L.; Creaney, J.; Lee, Y.C.; Stewart, G.A.
Mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation (2011), Biol. Chem., 392, 633-642.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	preplasma kallikrein activation on MeT-5A, NCI-H2052, NCI-H28 and primary murine mesothelial cells is strongly inhibited by 10 mM cysteine, 100 mM bradykinin, 100 mg/ml protamine sulfate and 5 mM novobiocin. Moderate inhibition is observed with 2-mercaptoethanol, 2-aminoethyl benzenesulfonyl fluoride, antipain and leupeptin on most cell lines. Angiotensin II, benzamidine and EDTA do not inhibit activation	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kininogen + H2O	Homo sapiens	-	bradykinin + fragments of kininogen	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pleural fluid	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
kininogen + H2O	-	Homo sapiens	bradykinin + fragments of kininogen	-	?

Expression

Organism	Comment	Expression
Homo sapiens	the plasma kallikrein amidolytic activity is significantly higher on mesothelial cells treated with malignant pleural effusions than compared to those cultured with benign effusions	up

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Release 2023.1 (January 2023)