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Literature summary for 3.4.21.34 extracted from

  • Sainz, I.M.; Pixley, R.A.; Colman, R.W.
    Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology (2007), Thromb. Haemost., 98, 77-83.
    View publication on PubMed
Search for more literature for 3.4.21.34

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XI + H2O Homo sapiens proteolytic activation, part of the coagulation cascade activated factor XI + ?
-
 ?
factor XII + H2O Homo sapiens proteolytic activation activated factor XII + ?
-
 ?
high-molecular-weight kininogen + H2O Homo sapiens pathways involving high-molecular-weight kininogen/high-molecular-weight kinin, overview high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
low-molecular-weight kininogen + H2O Homo sapiens
-
 low-molecular-weight kinin + kallidin kallidin is Lys-bradykinin or Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
additional information Homo sapiens plasma kallikrein activates neutrophil aggregation and degranulation, the enzyme is part of the kallikrein-kininogen-kinin system, KKS, kininogen plays a role in signaling pathways via the kininogen receptors, mechanism of inflammation related to KKS, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification prekallikrein is activated by factor XIIa Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O proteolytic activation Homo sapiens activated factor XI + ?
-
 ?
factor XI + H2O proteolytic activation, part of the coagulation cascade Homo sapiens activated factor XI + ?
-
 ?
factor XII + H2O proteolytic activation Homo sapiens activated factor XII + ?
-
 ?
high-molecular-weight kininogen + H2O
-
 Homo sapiens high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
high-molecular-weight kininogen + H2O pathways involving high-molecular-weight kininogen/high-molecular-weight kinin, overview Homo sapiens high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
low-molecular-weight kininogen + H2O
-
 Homo sapiens low-molecular-weight kinin + kallidin kallidin is Lys-bradykinin or Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
additional information plasma kallikrein activates neutrophil aggregation and degranulation, the enzyme is part of the kallikrein-kininogen-kinin system, KKS, kininogen plays a role in signaling pathways via the kininogen receptors, mechanism of inflammation related to KKS, overview Homo sapiens ?
-
 ?
additional information kininogen domain structure, overview Homo sapiens ?
-
 ?