Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antiprotease | - |
Homo sapiens | |
antithrombin | inhibition by antithrombin is 3.4fold improved by heparin, forming a ternary complex with antithrombin | Homo sapiens | |
C1-inhibitor | inhibition by C1-inhibitor is 1.4fold improved by heparin | Homo sapiens | |
heparin | improves inhibition by other enzyme inhibitor 1.4-3.4fold, the enzyme binds to a heparin-matrix, but its secondary structure is not modified by heparin, circular dichroism, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
plasminogen | pH 8.0, 37°C | Homo sapiens | |
0.00075 | - |
high-molecular-weight kininogen | pH 8.0, 37°C | Homo sapiens | |
0.0024 | - |
Factor XII | pH 8.0, 37°C | Homo sapiens | |
0.0049 | - |
2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine | pH 8.0, 37°C | Homo sapiens | |
0.269 | - |
H-D-Pro-Phe-Arg-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.736 | - |
acetyl-Phe-Arg-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
x * 88000 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme involved in intrinsic blood clotting, the kallikrein-kinin system and fibrinolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O | - |
Homo sapiens | 2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg + Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine | - |
? | |
acetyl-Phe-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
factor XII + H2O | proteolytic activation | Homo sapiens | activated factor XII + ? | - |
? | |
H-D-Pro-Phe-Arg-4-nitroanilide + H2O | i.e. S2302, a chromogenic substrate | Homo sapiens | ? | - |
? | |
high-molecular-weight kininogen + H2O | - |
Homo sapiens | high-molecular-weight kinin + bradykinin | bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | ? | |
additional information | the enzyme involved in intrinsic blood clotting, the kallikrein-kinin system and fibrinolysis | Homo sapiens | ? | - |
? | |
plasminogen + H2O | proteolytic activation | Homo sapiens | plasmin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 88000 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00034 | - |
plasminogen | pH 8.0, 37°C | Homo sapiens | |
0.001 | - |
Factor XII | pH 8.0, 37°C | Homo sapiens | |
0.0306 | - |
high-molecular-weight kininogen | pH 8.0, 37°C | Homo sapiens | |
0.1 | - |
2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine | pH 8.0, 37°C | Homo sapiens | |
37.7 | - |
acetyl-Phe-Arg-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
37.7 | - |
H-D-Pro-Phe-Arg-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics and secondorder rate constants | Homo sapiens |