Application | Comment | Organism |
---|---|---|
pharmacology | design of specific inhibitors for proteases like plasma kallikrein, but not protein C, to diminish the complement hydrolysis and coagulation during sepsis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-proteinase inhibitor-Leu-Gly-Arg | mutant of serpin alpha1-proteinase inhibitor with exchange at P3, P2 and P1 position, fast complexing, inhibition kinetics | Homo sapiens | |
alpha1-proteinase inhibitor-Pro-Phe-Arg | mutant of serpin alpha1-proteinase inhibitor with exchange at P3, P2 and P1 position, inhibition kinetics | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | plasma | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | involved in inflammatory processes via hydrolysis of complement | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Pro-Phe-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Pro-Phe-Arg + 4-nitroaniline | - |
ir | |
additional information | involved in inflammatory processes via hydrolysis of complement | Homo sapiens | ? | - |
? |