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Literature summary for 3.4.21.34 extracted from

  • Gozzo, A.J.; Nunes, V.A.; Carmona, A.K.; Nader, H.B.; von Dietrich, C.P.; Silveira, V.L.; Shimamoto, K.; Ura, N.; Sampaio, M.U.; Sampaio, C.A.; Araujo, M.S.
    Glycosaminoglycans affect the action of human plasma kallikrein on kininogen hydrolysis and inflammation (2002), Int. Immunopharmacol., 2, 1861-1865.
    View publication on PubMed
Search for more literature for 3.4.21.34

Inhibitors

Inhibitors Comment Organism Structure
bovine dermatan sulfate 68% inhibition at Homo sapiens
tuna dermatan sulfate 80% inhibition at Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00075
-
 kininogen pH 8.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble plasma Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41000
-
 x * 85000-88000, nonreducing SDS-PAGE, x * 33000-36000, light chain, + x * 41000, heavy chain, reducing SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kininogen + H2O Homo sapiens part of kallikrein-kininsystem bradykinin + fragment of kininogen bradykinin is a potent mediator of inflammatory response ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
48fold, affinity chromatography on soybean trypsin inhibitor-resin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma Cohn's fraction IV Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kininogen + H2O high-molecular weight substrate, serine protease Homo sapiens bradykinin + fragment of kininogen
-
 ?
kininogen + H2O part of kallikrein-kininsystem Homo sapiens bradykinin + fragment of kininogen bradykinin is a potent mediator of inflammatory response ir
o-aminobenzoyl-LGMISLMKRPPGFSPFRSSRI-NH2 + H2O
-
 Homo sapiens bradykinin + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 85000-88000, nonreducing SDS-PAGE, x * 33000-36000, light chain, + x * 41000, heavy chain, reducing SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.86
-
 kininogen pH 8.0, 37°C Homo sapiens
2.94
-
 kininogen pH 8.0, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens