Literature summary for 3.4.21.34 extracted from

Dulinski, R.; Suder, P.; Guevara-Lora, I.; Rapala-Kozik, M.; Potempa, J.; Silberring, J.; Imamura, T.; Travis, J.; Kozik, A.
Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins (2003), Biol. Chem., 384, 929-937.

Search for more literature for 3.4.21.34

Inhibitors

Inhibitors	Comment	Organism	Structure
Elastase	of human neutrophils, degrades kininogen itself to kinin-containing fragments and therefore quenches the kininogen degeneration/bradykinin generation by plasma kallikrein	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	plasma	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kininogen + H2O	Homo sapiens	high-molecular weight kininogen, involved in inflammatory reaction	bradykinin + fragments of kininogen	-	ir
modified kininogen + H2O	Homo sapiens	high-molecular weight kininogen digested by human neutrophil elastase	bradykinin + fragments of kininogen	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ISLMKRPPGFSPFRSSR + H2O	RPPGFSPFR is bradykinin, synthetic peptide containing the internal kinin sequence, 2 cleavage sites, the C-terminal one being preferred	Homo sapiens	ISLMKR + RPPGFSPFR + SSR	-	?
kininogen + H2O	high-molecular weight kininogen, preferred substrate	Homo sapiens	bradykinin + fragments of kininogen	-	?
kininogen + H2O	low-molecular weight kininogen, low activity	Homo sapiens	bradykinin + fragments of kininogen	-	?
kininogen + H2O	high-molecular weight kininogen, involved in inflammatory reaction	Homo sapiens	bradykinin + fragments of kininogen	-	ir
modified kininogen + H2O	high-molecular weight kininogen digested by human neutrophil elastase	Homo sapiens	bradykinin + fragments of kininogen	-	?
modified kininogen + H2O	high-molecular weight kininogen digested by human neutrophil elastase	Homo sapiens	bradykinin + fragments of kininogen	-	ir
modified kininogen + H2O	low-molecular weight kininogen digested by human neutrophil elastase, 26 amino acids cleaved off, is a better substrate than native low-molecular weight kininogen	Homo sapiens	bradykinin + fragments of kininogen	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)