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Literature summary for 3.4.21.27 extracted from

  • Al-Horani, R.A.; Gailani, D.; Desai, U.R.
    Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants (2015), Thromb. Res., 136, 379-387 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
decasodium 1,2,3,4,6-pentakis-O-[3,5-bis(sulfonatooxy)benzoyl]-beta-D-threo-hexopyranose complete inhibition at 1 mg/ml Homo sapiens
decasodium 1,2,3,4,6-pentakis-O-[4-hydroxy-3,5-bis(sulfonatooxy)benzoyl]-beta-D-threo-hexopyranose complete inhibition at 0.2 mg/ml Homo sapiens
additional information not inhibited by unfractionated heparin, enoxaparin, fondaparinux, sucrose octasulfate, chondroitin sulfate A, dermatan sulfate, and chondroitin sulfate C Homo sapiens
sulfated pentagalloyl beta-D-glucopyranoside
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens
-
activated factor IX + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor IX + H2O
-
Homo sapiens activated factor IX + ?
-
?
L-Glu-L-Glu-L-Pro-L-Arg-4-nitroanilide + H2O S-2366 Homo sapiens L-Glu-L-Glu-L-Pro-L-Arg + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
factor XIa
-
Homo sapiens
FXIa
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
at pH 7.4 and 37°C Homo sapiens decasodium 1,2,3,4,6-pentakis-O-[4-hydroxy-3,5-bis(sulfonatooxy)benzoyl]-beta-D-threo-hexopyranose
0.0014
-
at pH 7.4 and 37°C Homo sapiens decasodium 1,2,3,4,6-pentakis-O-[3,5-bis(sulfonatooxy)benzoyl]-beta-D-threo-hexopyranose