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Literature summary for 3.4.21.27 extracted from

  • Ge, X.; Yamaguchi, Y.; Zhao, L.; Bury, L.; Gresele, P.; Berube, C.; Leung, L.L.; Morser, J.
    Prochemerin cleavage by factor XIa links coagulation and inflammation (2018), Blood, 131, 353-364 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.27

Activating Compound

Activating Compound Comment Organism Structure
thrombin
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PN-2
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000103
-
 prochemerin chem163S at pH 7.4 and 37°C Homo sapiens
0.3
-
 factor IX 10-mer at pH 7.4 and 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 5 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens
-
 activated factor IX + ?
-
 ?
prochemerin chem163S + H2O Homo sapiens prochemerin is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin forms with different levels of activity chemerin chem162R + chermerin chem158K
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-LPRANSNH-C3H7 + H2O
-
 Homo sapiens D-LPR + ANSNH-C3H7
-
 ?
factor IX + H2O
-
 Homo sapiens activated factor IX + ?
-
 ?
factor IX 10-mer + H2O
-
 Homo sapiens ?
-
 ?
prochemerin chem163S + H2O prochemerin is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin forms with different levels of activity Homo sapiens chemerin chem162R + chermerin chem158K
-
 ?

Synonyms

Synonyms Comment Organism
factor XIa
-
 Homo sapiens
FXIa
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.083
-
 factor IX 10-mer at pH 7.4 and 37°C Homo sapiens
0.91
-
 prochemerin chem163S at pH 7.4 and 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
17
-
 factor IX 10-mer at pH 7.4 and 37°C Homo sapiens
530000
-
 prochemerin chem163S at pH 7.4 and 37°C Homo sapiens