BRENDA - Enzyme Database show
show all sequences of 3.4.21.27

Factor XI deficiency in animal models

Renne, T.; Oschatz, C.; Seifert, S.; Mueller, F.; Antovic, J.; Karlman, M.; Benz, P.M.; J. Thromb. Haemost. 7 Suppl 1, 79-83 (2009)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
activated factor XII
activates its substrate FXI
Homo sapiens
Factor XII
FXI is activated by factor XII during ischemia reperfusion injury and within the growing thrombus according to the classical intrinsic pathway cascade
Mus musculus
thrombin
thrombin generated early in coagulation by the tissue factor pathway activates FXI creating a positive feedback loop that sustains coagulation following inactivation of the factor VIIa/tissue factor complex by tissue factor pathway inhibitor
Homo sapiens
thrombin
-
Mus musculus
Application
Application
Commentary
Organism
medicine
therapeutically targeting FXI may offer a strategy for preventing or treating arterial thrombosis that is not associated with the high rate of hemorrhage that accompanies many currently used anticoagulants. Pharmacological FXI inhibitors may be beneficial in septic disease
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
80000
-
2 * 80000
Homo sapiens
80000
-
2 * 80000
Mus musculus
160000
-
-
Homo sapiens
160000
-
-
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Canis lupus familiaris
-
-
-
Didelphis sp.
-
-
-
Felis catus
-
-
-
Homo sapiens
P03951
-
-
Mus musculus
-
-
-
Ornithorhynchus anatinus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood plasma
-
Mus musculus
-
blood plasma
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Mus musculus
-
pancreas
-
Homo sapiens
-
Subunits
Subunits
Commentary
Organism
homodimer
2 * 80000
Mus musculus
homodimer
2 * 80000
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
activated factor XII
activates its substrate FXI
Homo sapiens
Factor XII
FXI is activated by factor XII during ischemia reperfusion injury and within the growing thrombus according to the classical intrinsic pathway cascade
Mus musculus
thrombin
thrombin generated early in coagulation by the tissue factor pathway activates FXI creating a positive feedback loop that sustains coagulation following inactivation of the factor VIIa/tissue factor complex by tissue factor pathway inhibitor
Homo sapiens
thrombin
-
Mus musculus
Application (protein specific)
Application
Commentary
Organism
medicine
therapeutically targeting FXI may offer a strategy for preventing or treating arterial thrombosis that is not associated with the high rate of hemorrhage that accompanies many currently used anticoagulants. Pharmacological FXI inhibitors may be beneficial in septic disease
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
80000
-
2 * 80000
Homo sapiens
80000
-
2 * 80000
Mus musculus
160000
-
-
Homo sapiens
160000
-
-
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood plasma
-
Homo sapiens
-
blood plasma
-
Mus musculus
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Mus musculus
-
pancreas
-
Homo sapiens
-
Subunits (protein specific)
Subunits
Commentary
Organism
homodimer
2 * 80000
Homo sapiens
homodimer
2 * 80000
Mus musculus
Expression
Organism
Commentary
Expression
Mus musculus
is predominantly, if not exclusively, expressed in the liver
up
General Information
General Information
Commentary
Organism
malfunction
probably due to inbreeding, presence of FXI deficiency
Canis lupus familiaris
malfunction
probably due to inbreeding, presence of FXI deficiency
Felis catus
malfunction
FXI deficient humans suffer from mild hemorrhage (hemophilia C), which is characterized by trauma or soft tissue-related hemorrhage, primarily involving tissues with high fibrinolytic activity. Bleeding severity in FXI deficiency is not associated with FXI plasma levels. Addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein
Homo sapiens
malfunction
addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein. FXI-/- mice are healthy, fertile, and phenotypically indistinguishable from wild-type animals. Mating between heterozygous FXI+/- mice follows the expected Mendelian ratio arguing against an association of FXI deficiency and increased risk of abortion. Plasma from FXI null mice show a severely prolonged activated partial thromboplastin time compared with wild-type animals. Bleeding times in adult FXI-/- mice are indistinguishable from wild-type animals, suggesting that FXI does not significantly contribute to fibrin formation. Formation of thrombi is severely defective in FXI-/- mice. Both fibrin deposition and platelet accumulation are reduced in FXI null mice compared with wild-type. FXI deficiency increases survival and reduces leukocyte infiltration and coagulopathy
Mus musculus
physiological function
the opossum genome has two distinct genes for both FXI and plasma kallikrein, indicating that the gene duplication event leading to separate factors occurred early in mammalian evolution
Didelphis sp.
physiological function
78% homology to human FXI at the protein level. FXI is critical for fibrin formation in vivo. FXI may have additional functions in regulation of inflammation or tissue repair distinct from its role in coagulation
Mus musculus
physiological function
presence of a single precursor of FXI and plasma kallikrein, appearance of FXI among early tetrapods
Ornithorhynchus anatinus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
probably due to inbreeding, presence of FXI deficiency
Canis lupus familiaris
malfunction
probably due to inbreeding, presence of FXI deficiency
Felis catus
malfunction
FXI deficient humans suffer from mild hemorrhage (hemophilia C), which is characterized by trauma or soft tissue-related hemorrhage, primarily involving tissues with high fibrinolytic activity. Bleeding severity in FXI deficiency is not associated with FXI plasma levels. Addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein
Homo sapiens
malfunction
addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein. FXI-/- mice are healthy, fertile, and phenotypically indistinguishable from wild-type animals. Mating between heterozygous FXI+/- mice follows the expected Mendelian ratio arguing against an association of FXI deficiency and increased risk of abortion. Plasma from FXI null mice show a severely prolonged activated partial thromboplastin time compared with wild-type animals. Bleeding times in adult FXI-/- mice are indistinguishable from wild-type animals, suggesting that FXI does not significantly contribute to fibrin formation. Formation of thrombi is severely defective in FXI-/- mice. Both fibrin deposition and platelet accumulation are reduced in FXI null mice compared with wild-type. FXI deficiency increases survival and reduces leukocyte infiltration and coagulopathy
Mus musculus
physiological function
the opossum genome has two distinct genes for both FXI and plasma kallikrein, indicating that the gene duplication event leading to separate factors occurred early in mammalian evolution
Didelphis sp.
physiological function
78% homology to human FXI at the protein level. FXI is critical for fibrin formation in vivo. FXI may have additional functions in regulation of inflammation or tissue repair distinct from its role in coagulation
Mus musculus
physiological function
presence of a single precursor of FXI and plasma kallikrein, appearance of FXI among early tetrapods
Ornithorhynchus anatinus
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
is predominantly, if not exclusively, expressed in the liver
up
Other publictions for EC 3.4.21.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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24
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24
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731538
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2015
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11
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2
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-
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-
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732318
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Phenylimidazoles as potent and ...
Homo sapiens
J. Med. Chem.
57
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2014
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35
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1
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3
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1
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1
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28
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1
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1
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1
35
28
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1
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1
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732897
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Homo sapiens
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2
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1
1
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2
2
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732936
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Homo sapiens
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133
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1
1
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731570
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Characterization of binding mo ...
Homo sapiens
Bull. Korean Chem. Soc.
34
1212-1220
2013
-
-
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-
42
-
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1
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1
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42
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1
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1
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-
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731773
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Factor XI and traveling waves: ...
Homo sapiens
Expert Rev. Hematol.
6
111-113
2013
2
-
-
-
-
-
-
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1
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1
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1
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1
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2
2
-
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-
731076
Fradera
High-resolution crystal struct ...
Homo sapiens
Acta Crystallogr. Sect. F
68
404-408
2012
-
-
1
1
1
-
2
-
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1
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1
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1
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1
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1
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1
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717416
Luszczak
Activated factor XI and tissue ...
Homo sapiens
Blood Coagul. Fibrinolysis
22
473-479
2011
-
-
-
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1
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3
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717844
Su
The role of factor XIa (FXIa) ...
Homo sapiens
J. Biol. Chem.
286
31904-31914
2011
1
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12
-
2
14
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1
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1
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1
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3
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14
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18
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1
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12
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2
18
14
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1
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1
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3
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14
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717958
Itakura
Activated factor XI inhibits c ...
Homo sapiens
J. Leukoc. Biol.
90
923-927
2011
-
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2
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1
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-
-
-
-
-
-
-
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1
1
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-
718045
Carrieri
The role of thrombin activatab ...
Homo sapiens
J. Thromb. Haemost.
9
154-162
2011
2
-
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2
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1
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1
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1
1
-
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-
707308
Schumacher
Inhibition of factor XIa as a ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Arterioscler. Thromb. Vasc. Biol.
30
388-392
2010
3
4
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4
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8
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1
4
4
1
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707856
Emsley
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Homo sapiens, Mus musculus
Blood
115
2569-2577
2010
7
-
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1
10
-
1
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1
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3
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2
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4
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7
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1
10
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1
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1
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2
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4
-
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-
-
-
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3
3
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710438
Maas
Activated factor V is a cofact ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
107
9083-9087
2010
1
-
1
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-
-
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1
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1
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1
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1
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1
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1
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1
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-
-
-
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717333
Hanessian
Design and synthesis of macroc ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
6925-6928
2010
-
-
-
-
-
-
5
-
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1
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5
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5
5
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717420
Cheng
A role for factor XIIa-mediate ...
Mus musculus
Blood
116
3981-3989
2010
2
-
-
-
-
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-
-
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1
-
7
-
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3
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2
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2
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3
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717742
Navaneetham
Mechanisms and specificity of ...
Homo sapiens
J. Biochem.
148
467-479
2010
-
-
-
-
-
-
10
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
10
9
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718042
Whelihan
Coagulation procofactor activa ...
Homo sapiens
J. Thromb. Haemost.
8
1532-1539
2010
1
-
-
-
-
-
-
-
-
1
1
3
-
1
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
1
3
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691011
Yang
Characterization of a heparin- ...
Homo sapiens
Biochemistry
48
1517-1524
2009
-
-
1
-
9
-
3
9
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
6
-
-
-
1
-
-
-
-
-
1
1
-
9
-
-
3
-
9
-
-
1
-
-
-
-
1
-
1
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
691466
Kravtsov
Factor XI contributes to throm ...
Homo sapiens
Blood
114
452-458
2009
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692544
Wang
A case of factor XI deficiency ...
Homo sapiens
Haemophilia
15
603-606
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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-
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-
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-
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-
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-
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-
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707134
Singh
Factor XI deficiency and obste ...
Homo sapiens
Anesth. Analg.
108
1882-1885
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
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-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707148
Franchini
The use of desmopressin in con ...
Homo sapiens
Ann. Hematol.
88
931-935
2009
1
1
-
-
-
-
-
-
-
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-
-
-
2
-
-
-
-
-
-
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-
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-
-
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-
-
-
-
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-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
709721
Gailani
Structural and functional feat ...
Homo sapiens
J. Thromb. Haemost.
7 Suppl 1
75-78
2009
4
-
-
-
-
-
-
-
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-
1
-
-
2
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
709722
Renne
Factor XI deficiency in animal ...
Canis lupus familiaris, Didelphis sp., Felis catus, Homo sapiens, Mus musculus, Ornithorhynchus anatinus
J. Thromb. Haemost.
7 Suppl 1
79-83
2009
4
1
-
-
-
-
-
-
-
-
4
-
-
8
-
-
-
-
-
6
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
6
-
-
-
2
-
-
-
-
-
-
-
-
1
7
7
1
-
-
710600
Livnat
Recombinant activated factor V ...
Homo sapiens
Thromb. Haemost.
102
487-492
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
683169
Schmidt
Functional role of residue 193 ...
Homo sapiens
Biochemistry
47
1326-1335
2008
-
-
1
-
6
-
4
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
4
-
1
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
4
-
3
-
1
-
-
-
-
-
1
-
-
-
-
4
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
683682
Smith
Characterization of novel form ...
Homo sapiens
J. Biol. Chem.
283
6696-6705
2008
-
-
1
-
2
-
1
3
1
-
-
1
-
1
-
1
1
-
-
2
1
-
4
1
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
1
1
3
1
-
-
1
-
-
1
1
-
2
1
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
691470
Kwon
Severe factor XI deficiency in ...
Homo sapiens
Blood Coagul. Fibrinolysis
19
679-683
2008
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693547
Buchanan
Clavatadine A, a natural produ ...
Homo sapiens
J. Med. Chem.
51
3583-3587
2008
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
1
-
2
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695184
Butenas
Factor XIa and tissue factor a ...
Homo sapiens
Thromb. Haemost.
99
142-149
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683160
Miller
A catalytic domain exosite (Cy ...
Homo sapiens
Biochemistry
46
14450-14460
2007
-
-
1
-
2
-
1
-
1
-
2
1
-
2
-
1
1
-
-
3
-
-
3
1
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
2
-
-
1
1
-
1
-
2
1
-
-
1
1
-
3
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683167
Sinha
Macromolecular substrate-bindi ...
Homo sapiens
Biochemistry
46
9830-9839
2007
-
-
1
-
-
-
2
4
1
1
-
1
-
1
-
1
-
-
-
2
-
-
3
1
1
-
-
4
-
-
-
-
6
-
-
-
-
1
-
-
-
-
-
2
6
4
1
1
-
1
-
-
1
-
-
2
-
-
3
1
1
-
-
4
-
-
-
-
-
-
-
-
-
-
684078
Mitchell
Characterisation of five facto ...
Homo sapiens
Thromb. Haemost.
97
884-889
2007
-
-
1
-
6
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683157
Rezaie
Contributions of basic amino a ...
Homo sapiens
Biochemistry
45
9427-9433
2006
-
-
1
-
6
-
5
-
1
-
-
1
-
1
-
1
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
6
-
-
5
1
-
1
-
-
1
-
-
1
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683239
Lazarova
Synthesis and in vitro biologi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
5022-5027
2006
-
-
-
-
-
-
8
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
7
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683756
Lin
Design, synthesis, and biologi ...
Homo sapiens
J. Med. Chem.
49
7781-7791
2006
1
1
1
1
1
-
30
-
1
-
-
1
-
3
-
1
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
30
1
1
1
-
1
1
-
30
30
-
-
1
-
-
1
-
-
1
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667059
Jin
Mutation of surface residues t ...
Homo sapiens
Acta Crystallogr. Sect. D
D61
1418-1425
2005
-
1
1
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667620
Sinha
Factor XIa dimer in the activa ...
Homo sapiens
Biochemistry
44
10416-10422
2005
3
1
1
-
1
-
-
2
-
-
4
-
-
1
-
-
1
-
-
-
-
-
3
2
1
-
-
-
-
-
-
-
-
-
-
3
1
1
-
-
1
-
-
-
-
2
-
-
4
-
-
-
-
1
-
-
-
-
3
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
669347
Ogawa
Exosite-mediated substrate rec ...
Homo sapiens
J. Biol. Chem.
280
23523-23530
2005
-
-
-
-
-
-
4
3
-
-
2
-
-
1
-
-
1
-
-
1
-
-
3
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
3
-
-
2
-
-
-
-
1
-
1
-
-
3
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
669392
Navaneetham
Structural and mutational anal ...
Homo sapiens
J. Biol. Chem.
280
36165-36175
2005
-
-
1
1
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669420
Jin
Crystal structures of the FXIa ...
Homo sapiens
J. Biol. Chem.
280
4704-4712
2005
3
1
1
1
-
-
3
-
-
-
2
-
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
3
1
1
-
1
-
-
-
3
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669428
Shi
Domain V of beta2-glycoprotein ...
Homo sapiens
J. Biol. Chem.
280
907-912
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667583
Pedicord
Substrate-dependent modulation ...
Homo sapiens
Biochemistry
43
11883-11888
2004
-
-
-
-
-
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
2
7
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
667611
Sinha
Allosteric modification of fac ...
Homo sapiens
Biochemistry
43
7593-7600
2004
-
-
-
-
-
-
4
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652309
Baird
The interaction of factor XIa ...
Homo sapiens
J. Biol. Chem.
277
38462-38467
2002
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652338
Peek
Unusual proteolytic activation ...
Homo sapiens
J. Biol. Chem.
277
47804-47809
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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