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Literature summary for 3.4.21.27 extracted from

  • Gailani, D.; Smith, S.B.
    Structural and functional features of factor XI (2009), J. Thromb. Haemost., 7 Suppl 1, 75-78.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.27

Activating Compound

Activating Compound Comment Organism Structure
activated factor XI
-
 Homo sapiens
activated factor XII FXI activation proceeds through an intermediate with only one activated submit Homo sapiens
additional information FXI monomers are activated poorly, dimeric form is needed for activation. As FXI lacks a Gla domain, the dimeric structure may represent an alternative solution to the problem of tethering a prothrombotic molecule to a cellular surface in flowing blood in the vicinity of a wound Homo sapiens
thrombin FXI activation proceeds through an intermediate with only one activated submit Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 2 * 80000 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P03951
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor IX + H2O FXI is converted to the active protease by cleavage of the Arg369-Ile370 bond on each subunit. This converts the catalytic domains to the active forms, and unmasks exosites on the apple domains required for FIX binding Homo sapiens activated factor IX + ?
-
 ?
kininogen + H2O binding to the A2 domain of FXI Homo sapiens ?
-
 ?
additional information FXI is a homodimer, with each subunit containing four apple domains and a protease domain: the apple domains form a disk structure with binding sites for platelets Homo sapiens ?
-
 ?
platelet glycoprotein 1balpha + H2O binding to the A3 domain of FXI Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 80000 Homo sapiens

Synonyms

Synonyms Comment Organism
factor XI
-
 Homo sapiens
FXI
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function FXI is the zymogen of a plasma protease that contributes to fibrin formation and stability by activating factor IX. Circulates in plasma in complex with high molecular weight kininogen Homo sapiens