Literature summary for 3.4.21.27 extracted from

Sinha, D.; Badellino, K.O.; Marcinkiewicz, M.; Walsh, P.N.
Allosteric modification of factor XIa functional activity upon binding to polyanions (2004), Biochemistry, 43, 7593-7600.

Search for more literature for 3.4.21.27

Inhibitors

Inhibitors	Comment	Organism	Structure
dextran sulfate M 10000	51% saturable maximal inhibition at 37°C	Homo sapiens
dextran sulfate M 500000	86% saturable maximal inhibition at 37°	Homo sapiens
fractionated heparin of 64 disaccharide units	70-80% saturable maximal inhibition at 37°C	Homo sapiens
hypersulfated heparin	54% saturable maximal inhibition at 37°C	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.4	-	L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
factor IX + H2O	-	Homo sapiens	factor IXa + ?	-	?
L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide + H2O	-	Homo sapiens	L-pyroglutamyl-L-prolyl-L-arginine + p-nitroaniline	-	?
N-Cbz-D-arginylglycyl-L-arginyl-4-nitroanilide + H2O	-	Homo sapiens	N-Cbz-D-arginylglycyl-L-arginine + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
activated factor XIa	-	Homo sapiens
factor XI	-	Homo sapiens
FXI	-	Homo sapiens
FXIa	-	Homo sapiens

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Release 2023.1 (January 2023)