BRENDA - Enzyme Database show
show all sequences of 3.4.21.27

Purification and characterization of human brain prolyl endopeptidase

Kalwant, S.; Porter, A.G.; Biochem. J. 276, 237-244 (1991)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
diisopropyl fluorophosphate
-
Homo sapiens
Zn2+
partially
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.09
-
benzyloxycarbonyl-Gly-Pro-p-nitroanilide
-
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
79600
-
1 * 79600, SDS-PAGE
Homo sapiens
85600
-
gel filtration
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.83
-
-
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
benzoxycarbonyl-Gly-Pro-p-nitroanilide
-
36541
Homo sapiens
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 79600, SDS-PAGE
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
diisopropyl fluorophosphate
-
Homo sapiens
Zn2+
partially
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.09
-
benzyloxycarbonyl-Gly-Pro-p-nitroanilide
-
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
79600
-
1 * 79600, SDS-PAGE
Homo sapiens
85600
-
gel filtration
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.83
-
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
benzoxycarbonyl-Gly-Pro-p-nitroanilide
-
36541
Homo sapiens
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 79600, SDS-PAGE
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
-
Homo sapiens
Other publictions for EC 3.4.21.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731462
Pinto
Structure-based design of inhi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
25
1635-1642
2015
-
-
-
-
-
-
33
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
33
-
-
-
-
-
-
-
-
-
-
33
33
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731466
Corte
Pyridine and pyridinone-based ...
Homo sapiens
Bioorg. Med. Chem. Lett.
25
925-930
2015
-
-
-
-
-
-
25
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
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-
-
-
-
-
-
24
-
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-
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-
-
-
25
24
-
-
-
-
1
-
-
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-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731538
Puy
Activated factor XI increases ...
Homo sapiens
Blood
125
1488-1496
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
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-
-
-
-
-
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-
2
-
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-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732313
Argade
Allosteric inhibition of human ...
Homo sapiens
J. Med. Chem.
57
3559-3569
2014
-
-
-
-
-
-
11
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
732318
Hangeland
Phenylimidazoles as potent and ...
Homo sapiens
J. Med. Chem.
57
9915-9932
2014
-
-
-
1
-
-
35
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
28
-
1
-
-
-
-
1
-
-
1
35
28
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
732897
Faid
Site-specific N-glycosylation ...
Homo sapiens
Proteomics
14
2460-2470
2014
-
-
-
-
-
-
-
-
-
-
2
1
-
3
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
732936
Gailani
-
The mechanism underlying activ ...
Homo sapiens
Thromb. Res.
133
S48-S51
2014
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731570
Cho
-
Characterization of binding mo ...
Homo sapiens
Bull. Korean Chem. Soc.
34
1212-1220
2013
-
-
-
-
-
-
42
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
42
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731773
Ataullakhanov
Factor XI and traveling waves: ...
Homo sapiens
Expert Rev. Hematol.
6
111-113
2013
2
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
731076
Fradera
High-resolution crystal struct ...
Homo sapiens
Acta Crystallogr. Sect. F
68
404-408
2012
-
-
1
1
1
-
2
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
2
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717416
Luszczak
Activated factor XI and tissue ...
Homo sapiens
Blood Coagul. Fibrinolysis
22
473-479
2011
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717844
Su
The role of factor XIa (FXIa) ...
Homo sapiens
J. Biol. Chem.
286
31904-31914
2011
1
-
-
-
12
-
2
14
-
-
-
-
-
1
-
-
1
-
-
1
-
-
3
-
-
-
-
14
-
-
-
-
18
-
-
1
-
-
-
-
12
-
-
2
18
14
-
-
-
-
-
-
-
1
-
1
-
-
3
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
717958
Itakura
Activated factor XI inhibits c ...
Homo sapiens
J. Leukoc. Biol.
90
923-927
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
718045
Carrieri
The role of thrombin activatab ...
Homo sapiens
J. Thromb. Haemost.
9
154-162
2011
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707308
Schumacher
Inhibition of factor XIa as a ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Arterioscler. Thromb. Vasc. Biol.
30
388-392
2010
3
4
-
-
-
-
4
-
-
-
-
-
-
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
4
4
1
-
-
707856
Emsley
Structure and function of fact ...
Homo sapiens, Mus musculus
Blood
115
2569-2577
2010
7
-
-
1
10
-
1
-
-
1
-
-
-
3
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
1
10
-
-
1
-
-
-
1
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
710438
Maas
Activated factor V is a cofact ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
107
9083-9087
2010
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
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-
-
-
-
-
-
-
-
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-
1
-
1
-
-
-
-
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-
-
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-
-
-
-
-
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-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717333
Hanessian
Design and synthesis of macroc ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
6925-6928
2010
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
5
5
-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717420
Cheng
A role for factor XIIa-mediate ...
Mus musculus
Blood
116
3981-3989
2010
2
-
-
-
-
-
-
-
-
-
-
1
-
7
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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2
-
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-
-
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-
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-
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1
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3
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717742
Navaneetham
Mechanisms and specificity of ...
Homo sapiens
J. Biochem.
148
467-479
2010
-
-
-
-
-
-
10
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
10
9
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718042
Whelihan
Coagulation procofactor activa ...
Homo sapiens
J. Thromb. Haemost.
8
1532-1539
2010
1
-
-
-
-
-
-
-
-
1
1
3
-
1
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
1
3
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691011
Yang
Characterization of a heparin- ...
Homo sapiens
Biochemistry
48
1517-1524
2009
-
-
1
-
9
-
3
9
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
6
-
-
-
1
-
-
-
-
-
1
1
-
9
-
-
3
-
9
-
-
1
-
-
-
-
1
-
1
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
691466
Kravtsov
Factor XI contributes to throm ...
Homo sapiens
Blood
114
452-458
2009
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692544
Wang
A case of factor XI deficiency ...
Homo sapiens
Haemophilia
15
603-606
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
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1
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707134
Singh
Factor XI deficiency and obste ...
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1
1
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707148
Franchini
The use of desmopressin in con ...
Homo sapiens
Ann. Hematol.
88
931-935
2009
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1
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1
1
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709721
Gailani
Structural and functional feat ...
Homo sapiens
J. Thromb. Haemost.
7 Suppl 1
75-78
2009
4
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1
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1
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4
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1
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1
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4
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
709722
Renne
Factor XI deficiency in animal ...
Canis lupus familiaris, Didelphis sp., Felis catus, Homo sapiens, Mus musculus, Ornithorhynchus anatinus
J. Thromb. Haemost.
7 Suppl 1
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8
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-
6
-
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2
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4
1
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4
-
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-
-
6
-
-
-
2
-
-
-
-
-
-
-
-
1
7
7
1
-
-
710600
Livnat
Recombinant activated factor V ...
Homo sapiens
Thromb. Haemost.
102
487-492
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
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-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
683169
Schmidt
Functional role of residue 193 ...
Homo sapiens
Biochemistry
47
1326-1335
2008
-
-
1
-
6
-
4
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
4
-
1
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
4
-
3
-
1
-
-
-
-
-
1
-
-
-
-
4
-
1
-
-
2
1
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-
683682
Smith
Characterization of novel form ...
Homo sapiens
J. Biol. Chem.
283
6696-6705
2008
-
-
1
-
2
-
1
3
1
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1
-
1
-
1
1
-
-
2
1
-
4
1
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
1
1
3
1
-
-
1
-
-
1
1
-
2
1
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
691470
Kwon
Severe factor XI deficiency in ...
Homo sapiens
Blood Coagul. Fibrinolysis
19
679-683
2008
-
-
-
-
1
-
-
-
-
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2
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-
1
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-
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-
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-
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-
-
-
-
-
-
-
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693547
Buchanan
Clavatadine A, a natural produ ...
Homo sapiens
J. Med. Chem.
51
3583-3587
2008
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-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
1
-
2
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
695184
Butenas
Factor XIa and tissue factor a ...
Homo sapiens
Thromb. Haemost.
99
142-149
2008
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-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
2
-
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2
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-
683160
Miller
A catalytic domain exosite (Cy ...
Homo sapiens
Biochemistry
46
14450-14460
2007
-
-
1
-
2
-
1
-
1
-
2
1
-
2
-
1
1
-
-
3
-
-
3
1
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
2
-
-
1
1
-
1
-
2
1
-
-
1
1
-
3
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683167
Sinha
Macromolecular substrate-bindi ...
Homo sapiens
Biochemistry
46
9830-9839
2007
-
-
1
-
-
-
2
4
1
1
-
1
-
1
-
1
-
-
-
2
-
-
3
1
1
-
-
4
-
-
-
-
6
-
-
-
-
1
-
-
-
-
-
2
6
4
1
1
-
1
-
-
1
-
-
2
-
-
3
1
1
-
-
4
-
-
-
-
-
-
-
-
-
-
684078
Mitchell
Characterisation of five facto ...
Homo sapiens
Thromb. Haemost.
97
884-889
2007
-
-
1
-
6
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683157
Rezaie
Contributions of basic amino a ...
Homo sapiens
Biochemistry
45
9427-9433
2006
-
-
1
-
6
-
5
-
1
-
-
1
-
1
-
1
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
6
-
-
5
1
-
1
-
-
1
-
-
1
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
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-
683239
Lazarova
Synthesis and in vitro biologi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
5022-5027
2006
-
-
-
-
-
-
8
-
-
-
-
1
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
7
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
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683756
Lin
Design, synthesis, and biologi ...
Homo sapiens
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49
7781-7791
2006
1
1
1
1
1
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30
-
1
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1
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3
-
1
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-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
30
1
1
1
-
1
1
-
30
30
-
-
1
-
-
1
-
-
1
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
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-
667059
Jin
Mutation of surface residues t ...
Homo sapiens
Acta Crystallogr. Sect. D
D61
1418-1425
2005
-
1
1
1
-
-
1
-
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1
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1
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-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
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-
667620
Sinha
Factor XIa dimer in the activa ...
Homo sapiens
Biochemistry
44
10416-10422
2005
3
1
1
-
1
-
-
2
-
-
4
-
-
1
-
-
1
-
-
-
-
-
3
2
1
-
-
-
-
-
-
-
-
-
-
3
1
1
-
-
1
-
-
-
-
2
-
-
4
-
-
-
-
1
-
-
-
-
3
2
1
-
-
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-
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669347
Ogawa
Exosite-mediated substrate rec ...
Homo sapiens
J. Biol. Chem.
280
23523-23530
2005
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-
-
-
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4
3
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2
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1
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1
-
-
1
-
-
3
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
3
-
-
2
-
-
-
-
1
-
1
-
-
3
1
-
-
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3
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-
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669392
Navaneetham
Structural and mutational anal ...
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J. Biol. Chem.
280
36165-36175
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1
1
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2
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2
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1
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-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
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669420
Jin
Crystal structures of the FXIa ...
Homo sapiens
J. Biol. Chem.
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2005
3
1
1
1
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3
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2
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4
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1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
3
1
1
-
1
-
-
-
3
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
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-
-
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669428
Shi
Domain V of beta2-glycoprotein ...
Homo sapiens
J. Biol. Chem.
280
907-912
2005
-
-
-
-
-
-
-
-
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2
-
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-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667583
Pedicord
Substrate-dependent modulation ...
Homo sapiens
Biochemistry
43
11883-11888
2004
-
-
-
-
-
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
2
7
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
667611
Sinha
Allosteric modification of fac ...
Homo sapiens
Biochemistry
43
7593-7600
2004
-
-
-
-
-
-
4
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
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-
-
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-
652309
Baird
The interaction of factor XIa ...
Homo sapiens
J. Biol. Chem.
277
38462-38467
2002
-
-
-
-
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1
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-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
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-
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-
652338
Peek
Unusual proteolytic activation ...
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277
47804-47809
2002
-
-
-
-
-
-
-
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1
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650724
Gailani
Model for a factor IX activati ...
Homo sapiens
Blood
97
3117-3122
2001
-
-
-
-
1
-
-
6
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
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6
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
649981
Badellino
Protease nexin II interactions ...
Homo sapiens
Biochemistry
39
4769-4777
2000
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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652013
Baglia
Thrombin-mediated feedback act ...
Homo sapiens
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275
20514-20519
2000
-
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1
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-
1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
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1
-
-
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36540
Zhang
The mechanism by which heparin ...
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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36538
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Coagulation factor XIa cleaves ...
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26265-26269
1995
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36539
Naito
Activation of human blood coag ...
Homo sapiens
J. Biol. Chem.
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1991
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36541
Kalwant
Purification and characterizat ...
Homo sapiens
Biochem. J.
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1991
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36531
Meijers
Inhibition of human blood coag ...
Homo sapiens
Biochemistry
27
959-963
1988
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36537
Kam
Mechanism-based isocoumarin in ...
Homo sapiens
Biochemistry
27
2547-2557
1988
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3
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4
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9
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36536
Sinha
Role of calcium ions and the h ...
Homo sapiens
Biochemistry
26
3768-3775
1987
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36529
Scott
Human factor XIa cleaves fibri ...
Homo sapiens
Arch. Biochem. Biophys.
249
480-488
1986
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5
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36530
Sinha
Functional characterization of ...
Homo sapiens
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1985
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36532
Van der Graaf
Isolation and functional chara ...
Homo sapiens
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258
9669-9675
1983
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31351
Lindquist
Activation of bovine factor IX ...
Bos taurus
J. Biol. Chem.
253
1902-1909
1978
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36534
Koide
Bovine factor XI (plasma throm ...
Bos taurus
Methods Enzymol.
45
65-73
1976
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1
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36535
Fujikawa
The mechanism of activation of ...
Bos taurus
Biochemistry
13
4508-4516
1974
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