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Literature summary for 3.4.21.27 extracted from
- Isolation and functional characterization of the active light chain of activated human blood coagulation factor XI (1983), J. Biol. Chem., 258, 9669-9675.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.56 | - |
pyroGlu-Pro-Arg-p-nitroanilide | - |
Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | substrate factor IX: Ca2+ activates | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
x * 35000, x * 48000, SDS-PAGE, 2 chains | Homo sapiens |
| 48000 | - |
x * 35000, x * 48000, SDS-PAGE, 2 chains | Homo sapiens |
| 160000 | - |
x * 160000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | Homo sapiens | activation of Factor IX in the intrinsic coagulation cascade | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | activation of Factor IX in the intrinsic coagulation cascade | Homo sapiens | ? | - |
? | |
| factor IX + H2O | - |
Homo sapiens | factor IXa + peptide | - |
? | |
| pyroGlu-Pro-Arg-p-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 160000, SDS-PAGE | Homo sapiens |
| polymer | x * 35000, x * 48000, SDS-PAGE, 2 chains | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 350 | - |
pyroGlu-Pro-Arg-p-nitroanilide | - |
Homo sapiens | |
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