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Literature summary for 3.4.21.26 extracted from
- Prolyl oligopeptidase from the blood fluke Schistosoma mansoni From functional analysis to anti-schistosomal inhibitors (2015), PLoS Negl. Trop. Dis., 9, e0003827 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Schistosoma mansoni |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,4-dichloroisocoumarin | - |
Homo sapiens |  |
| 3,4-dichloroisocoumarin | 77.3% inhibition at 0.1 mM | Schistosoma mansoni | |
| antipain | - |
Homo sapiens | |
| antipain | 32.4% inhibition at 0.02 mM | Schistosoma mansoni | |
| Aprotinin | - |
Homo sapiens | |
| Aprotinin | 1.4% inhibition at 0.05 mM | Schistosoma mansoni | |
| benzamidine | - |
Homo sapiens | |
| benzamidine | 3.7% inhibition at 0.01 mM | Schistosoma mansoni | |
| bestatin | - |
Homo sapiens | |
| bestatin | 2.3% inhibition at 0.001 mM | Schistosoma mansoni | |
| diisopropyl fluorophosphate | - |
Homo sapiens | |
| diisopropyl fluorophosphate | complete inhibition at 0.1 mM | Schistosoma mansoni | |
| E64 | - |
Homo sapiens | |
| E64 | 6.5% inhibition at 0.01 mM | Schistosoma mansoni | |
| EDTA | - |
Homo sapiens | |
| EDTA | 3.8% inhibition at 1 mM | Schistosoma mansoni | |
| leupeptin | - |
Homo sapiens | |
| leupeptin | 2.3% inhibition at 0.02 mM | Schistosoma mansoni | |
| N-p-tosyl-L-phenylalanine chloromethylketone | 67.2% inhibition at 0.001 mM | Schistosoma mansoni | |
| N-p-tosyl-L-phenylalanine-chloromethylketone | - |
Homo sapiens | |
| Nalpha-tosyl-L-lysine chloromethylketone | 38.3% inhibition at 0.001 mM | Schistosoma mansoni | |
| Nalpha-tosyl-L-lysine-chloromethylketone | - |
Homo sapiens | |
| Pefabloc SC | - |
Homo sapiens | |
| Pefabloc SC | 12% inhibition at 1 mM | Schistosoma mansoni | |
| pepstatin A | - |
Homo sapiens | |
| pepstatin A | 7.3% inhibition at 0.001 mM | Schistosoma mansoni | |
| phenylmethylsulfonyl fluoride | - |
Homo sapiens | |
| phenylmethylsulfonyl fluoride | 47.6% inhibition at 1 mM | Schistosoma mansoni | |
| Soybean trypsin inhibitor | - |
Homo sapiens | |
| Soybean trypsin inhibitor | 12.3% inhibition at 0.01 mM | Schistosoma mansoni | |
| SUAM 14746 | i.e. 3-([4-[2-(E)-styrylphenoxy]butanoyl]-L-4-hydroxyprolyl)thiazolidine | Homo sapiens | |
| SUAM 14746 | i.e. 3-([4-[2-(E)-styrylphenoxy]butanoyl]-L-4-hydroxyprolyl)thiazolidine | Schistosoma mansoni | |
| Y-29794 oxalate | - |
Homo sapiens | |
| Y-29794 oxalate | - |
Schistosoma mansoni | |
| Z-Ala-Pro-aldehyde | - |
Homo sapiens | |
| Z-Ala-Pro-aldehyde | - |
Schistosoma mansoni | |
| Z-Ala-Pro-chloromethylketone | - |
Homo sapiens | |
| Z-Ala-Pro-chloromethylketone | complete inhibition at 0.001 mM | Schistosoma mansoni | |
| Z-Arg-Pro-aldehyde | - |
Homo sapiens | |
| Z-Arg-Pro-aldehyde | - |
Schistosoma mansoni | |
| Z-Arg-Pro-chloromethylketone | - |
Homo sapiens | |
| Z-Arg-Pro-chloromethylketone | - |
Schistosoma mansoni | |
| Z-Gly-Pro-aldehyde | - |
Homo sapiens | |
| Z-Gly-Pro-aldehyde | - |
Schistosoma mansoni | |
| Z-Lys-Pro-aldehyde | - |
Homo sapiens | |
| Z-Lys-Pro-aldehyde | - |
Schistosoma mansoni | |
| Z-Pro | - |
Homo sapiens | |
| Z-Pro | 41.1% inhibition at 0.1 mM | Schistosoma mansoni | |
| Z-Pro-Pro | - |
Homo sapiens | |
| Z-Pro-Pro | 37.6% inhibition at 0.1 mM | Schistosoma mansoni | |
| Z-Pro-Pro-aldehyde | - |
Homo sapiens | |
| Z-Pro-Pro-aldehyde | complete inhibition at 0.001 mM | Schistosoma mansoni | |
| Z-Tyr-Pro-aldehyde | - |
Homo sapiens | |
| Z-Tyr-Pro-aldehyde | - |
Schistosoma mansoni | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Schistosoma mansoni | W8GKU3 | blood fluke | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Hi-Trap column chromatography and Mono Q column chromatography | Schistosoma mansoni |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult | - |
Schistosoma mansoni | - |
| cercaria | - |
Schistosoma mansoni | - |
| egg | - |
Schistosoma mansoni | - |
| integument | - |
Schistosoma mansoni | - |
| miracidium | - |
Schistosoma mansoni | - |
| additional information | not observed in the gastrodermis, gut lumen and muscular tissues | Schistosoma mansoni | - |
| parenchyma | - |
Schistosoma mansoni | - |
| sporocyst | - |
Schistosoma mansoni | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O | about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Homo sapiens | Abz-Ala-Ala-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O | about 50% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Schistosoma mansoni | Abz-Ala-Ala-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O | about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Homo sapiens | Abz-Ala-Pro + L-Ala-4-nitrophenylalanine | - |
? | |
| Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O | about 27% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Schistosoma mansoni | Abz-Ala-Pro + L-Ala-4-nitrophenylalanine | - |
? | |
| Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O | about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Homo sapiens | Abz-Ala-Pro + Gly-4-nitrophenylalanine | - |
? | |
| Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O | about 40% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Schistosoma mansoni | Abz-Ala-Pro + Gly-4-nitrophenylalanine | - |
? | |
| Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O | about 2% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Homo sapiens | Abz-Gly-Gly-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O | about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Schistosoma mansoni | Abz-Gly-Gly-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Gly-Pro-4-nitrophenylalanine + H2O | about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Schistosoma mansoni | Abz-Gly-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Gly-Pro-4-nitrophenylalanine + H2O | about 7% activity compared to Abz-Lys-Pro-4-nitrophenylalanine | Homo sapiens | Abz-Gly-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Lys-Pro-4-nitrophenylalanine + H2O | 100% activity | Homo sapiens | Abz-Lys-Pro + 4-nitrophenylalanine | - |
? | |
| Abz-Lys-Pro-4-nitrophenylalanine + H2O | 100% activity | Schistosoma mansoni | Abz-Lys-Pro + 4-nitrophenylalanine | - |
? | |
| alpha-melanocyte-stimulating hormone + H2O | acetyl-SYSMEHFRWGKPV | Schistosoma mansoni | acetyl-SYSMEHFRWGKP + L-Val | - |
? | |
| angiotensin I + H2O | DRVYIHPFHL | Schistosoma mansoni | DRVYIHP + FHL | - |
? | |
| angiotensin II + H2O | DRVYIHPF | Schistosoma mansoni | DRVYIHP + L-Phe | - |
? | |
| bradykinin + H2O | RPPGFSPFR | Schistosoma mansoni | RPP + GFSP + L-Phe-L-Arg | - |
? | |
| L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O | about 3% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin | Schistosoma mansoni | L-Lys-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O | about 5% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin | Homo sapiens | L-Lys-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| luteinizing-hormone-releasing hormone + H2O | pEHWSYGLRPG | Schistosoma mansoni | pEHWSYGLRP + Gly | - |
? | |
| additional information | no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin | Homo sapiens | ? | - |
? | |
| additional information | no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin | Schistosoma mansoni | ? | - |
? | |
| additional information | no activity with human hemoglobin, human serum albumin, human collagen type I, and human collagen type IV | Schistosoma mansoni | ? | - |
? | |
| neurotensin + H2O | pELYENKPRRPYIL | Schistosoma mansoni | pELYENKP + RRP + YIL | - |
? | |
| oxytocin + H2O | CYIQNCPLG | Schistosoma mansoni | CYIQNCP + L-Leu-Gly | - |
? | |
| substance P + H2O | RPKPQQFFGLM | Schistosoma mansoni | RPKP + QQFFGLM | - |
? | |
| succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O | about 58% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin | Homo sapiens | succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
| succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O | about 65% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin | Schistosoma mansoni | succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
| vassopresin + H2O | CYFQNCPRG | Schistosoma mansoni | CYFQNCP + L-Arg-Gly | - |
? | |
| Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 87% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 40% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 10% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 5% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 18% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O | 100% activity | Schistosoma mansoni | Z-Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 22% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 58% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 92% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | 100% activity | Homo sapiens | Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | 100% activity | Schistosoma mansoni | Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 67% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 68% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 48% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 75% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 23% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
| Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O | about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin | Schistosoma mansoni | Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 80000, SDS-PAGE | Schistosoma mansoni |
| ? | x * 82000, calculated from amino acid sequence | Schistosoma mansoni |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| POP | - |
Homo sapiens |
| POP | - |
Schistosoma mansoni |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Schistosoma mansoni |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 10 | about 30% activity at pH 6.0, about 70% activity at pH 7.0, 100% activity at pH 8.0, about 60% activity at pH 9.0, about 40% activity at pH 10.0, no enzyme activity below pH 5.0 | Schistosoma mansoni |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000029 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Arg-Pro-chloromethylketone | |
| 0.0000032 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Ala-Pro-chloromethylketone | |
| 0.0000048 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Arg-Pro-chloromethylketone | |
| 0.000012 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Pro-Pro-aldehyde | |
| 0.0000168 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Ala-Pro-chloromethylketone | |
| 0.000083 | - |
at pH 8.0 and 37°C | Homo sapiens | SUAM 14746 | |
| 0.000092 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | SUAM 14746 | |
| 0.00016 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Pro-Pro-aldehyde | |
| 0.00049 | - |
at pH 8.0 and 37°C | Homo sapiens | Y-29794 oxalate | |
| 0.0013 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Arg-Pro-aldehyde | |
| 0.0024 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Arg-Pro-aldehyde | |
| 0.003 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Lys-Pro-aldehyde | |
| 0.0031 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Ala-Pro-aldehyde | |
| 0.0044 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Tyr-Pro-aldehyde | |
| 0.0061 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Ala-Pro-aldehyde | |
| 0.0061 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Z-Gly-Pro-aldehyde | |
| 0.0072 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Lys-Pro-aldehyde | |
| 0.0076 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Gly-Pro-aldehyde | |
| 0.0086 | - |
at pH 8.0 and 37°C | Schistosoma mansoni | Y-29794 oxalate | |
| 0.011 | - |
at pH 8.0 and 37°C | Homo sapiens | Z-Tyr-Pro-aldehyde | |
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Release 2023.1 (January 2023)
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