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Literature summary for 3.4.21.26 extracted from

  • Poplawski, S.E.; Lai, J.H.; Li, Y.; Jin, Z.; Liu, Y.; Wu, W.; Wu, Y.; Zhou, Y.; Sudmeier, J.L.; Sanford, D.G.; Bachovchin, W.W.
    Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase (2013), J. Med. Chem., 56, 3467-3477.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(S)-valinyl-(R)-boroproline
-
Homo sapiens
1-(2-(1-oxoisoindolin-2-acetyl))-(R)-boroproline
-
Homo sapiens
ARI-3099 i.e. N-(pyridine-4-carbonyl)-D-Ala-boro-L-Pro Homo sapiens
ARI-3531 selective inhibitor, i.e. N-(pyridine-3-carbonyl)-L-Val-boroproline Homo sapiens
glycinyl-(R)-boroproline
-
Homo sapiens
N-(1-naphthalenecarbonyl)glycinyl-(R)-boroproline
-
Homo sapiens
N-(benzoyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-2-chloro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-2-fluoro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-3-carbonyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-3-carbonyl)glycinyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-3-chloro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-3-fluoro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(pyridine-4-carbonyl)glycinyl-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-butyl(glycinyl)-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-ethyl(glycinyl)-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-methioninyl-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-phenyl(glycinyl)-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-propyl(glycinyl)-(R)-boroproline
-
Homo sapiens
N-(quinoline-4-carbonyl)-(R)-serinyl-(R)-boroproline
-
Homo sapiens
N-acetyl-(R)-alaninyl-(R)-boroproline
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
-
Homo sapiens z-Gly-Pro + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
PREP
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000073
-
ARI-3099 at 25┬░C, pH not specified in the publication Homo sapiens
0.0000031
-
ARI-3531 at 25┬░C, pH not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000013
-
at 25┬░C, pH not specified in the publication Homo sapiens ARI-3531
0.013
-
at 25┬░C, pH not specified in the publication Homo sapiens ARI-3099