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Literature summary for 3.4.21.26 extracted from

  • Moreno-Baylach, M.J.; Puttonen, K.A.; Tenorio-Laranga, J.; Venaelaeinen, J.I.; Storvik, M.; Forsberg, M.M.; Garcia-Horsman, J.A.
    Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells (2011), Neurosignals, 19, 97-109.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
JTP-4819 i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N(phenylmethyl)-1-pyrrolidinecarboxamide Homo sapiens
KYP-2047 i.e. 4-phenylbutanoyl-L-prolyl-2(S)Ā–cyanopyrrolidine Homo sapiens
Z-Pro-prolinal
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm enzyme activity is located only in the cytoplasm during maturation and ageing Homo sapiens 5737
-
nucleus enzyme activity is located within the nuclei of pre-neurons Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
PEP
-
Homo sapiens
POP
-
Homo sapiens
PREP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens cytoplasmic PREP activity decreases slowly and steadily from DIV 0 throughout the growth curve until reaching confluence (between DIV 10 and 15) down
Homo sapiens PREP activity inside the nucleus increases 3fold at DIV 1 compared with its initial levels, PREP nuclearactivity decline dramatically until the cells reach confluence (right after DIV 10) up