Cloned (Comment) | Organism |
---|---|
expressed in Hi5 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxo- ethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2- carbonitrile | potent and selective inhibitor of FAP, 0.01 mM used in assay conditions | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpa2-antiplasmin + H2O | Homo sapiens | not a robust substrate in vitro, the enzyme cleaves after Pro12 in the T9S10G11P12-N13 Q14E15Q16E17 sequence | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation and Ni-Sepharose resin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpa2-antiplasmin + H2O | not a robust substrate in vitro, the enzyme cleaves after Pro12 in the T9S10G11P12-N13 Q14E15Q16E17 sequence | Homo sapiens | ? | - |
? | |
additional information | fibroblast activation protein prefers uncharged residues, including small or bulky hydrophobic amino acids, but not charged amino acids, especially acidic residue at P1, P3 and P4 sites. Fibroblast activation protein cannot cleave interleukins | Homo sapiens | ? | - |
? | |
SPRY2 + H2O | not an in vivo substrate of fibroblast activation protein | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAP | - |
Homo sapiens |
fibroblast activation protein | - |
Homo sapiens |
prolyl endopeptidase | - |
Homo sapiens |