Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.26 extracted from

  • Peltonen, I.; Maennistoe, P.T.
    Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase (2011), Basic Clin. Pharmacol. Toxicol., 108, 46-54.
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
buspirone 25% inhibition at 0.01 mM Rattus norvegicus
chlorpromazine 55% inhibition at 0.01 mM Rattus norvegicus
citalopram 27% inhibition at 0.01 mM Rattus norvegicus
clozapine 40% inhibition at 0.01 mM Rattus norvegicus
desipramine 20% inhibition at 0.01 mM Rattus norvegicus
duloxetine 21% inhibition at 0.01 mM Rattus norvegicus
escitalopram 39% inhibition at 0.01 mM Rattus norvegicus
flupenthixol 56% inhibition at 0.01 mM Rattus norvegicus
imipramine 29% inhibition at 0.01 mM Rattus norvegicus
ketanserin mixed type inhibitor, 49% inhibition at 0.01 mM Rattus norvegicus
lamotrigine 22% inhibition at 0.01 mM Rattus norvegicus
levomepromazine 32% inhibition at 0.01 mM Rattus norvegicus
mianserin 15% inhibition at 0.01 mM Rattus norvegicus
additional information not inhibited by carbamazepine, bupropion, diazepam, fluoxetine, haloperidol, lithium, maprotiline, mirtazapine, moclobemide, pargyline, pinoline, scopolamine, selegiline, sulpiride, venlafaxine, and valpraote at 0.01 mM concentration Rattus norvegicus
pimozide 11% inhibition at 0.01 mM Rattus norvegicus
prazosin 91% inhibition at 0.01 mM Rattus norvegicus
prochlorperazine 77% inhibition at 0.01 mM Rattus norvegicus
promazine 64% inhibition at 0.01 mM Rattus norvegicus
reboxetine 13% inhibition at 0.01 mM Rattus norvegicus
reserpine 18% inhibition at 0.01 mM Rattus norvegicus
risperidone 56% inhibition at 0.01 mM Rattus norvegicus
ritanserin 33% inhibition at 0.01 mM Rattus norvegicus
thioridazine non-competitive inhibitor, 91% inhibition at 0.01 mM Rattus norvegicus
Valproate competitive inhibitor, 56% inhibition at 0.5 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
POP
-
 Rattus norvegicus