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Literature summary for 3.4.21.26 extracted from

  • Tenorio-Laranga, J.; Coret-Ferrer, F.; Casanova-Estruch, B.; Burgal, M.; Garcia-Horsman, J.A.
    Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis (2010), J. Neuroinflammation, 7, 23.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.26

Activating Compound

Activating Compound Comment Organism Structure
additional information decrease in enzyme activity in plasma of relapsing remitting multiple sclerose patients Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-Pro-prolinal
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, ion exchange chromatography Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Gly-Pro-7-amido-4-methylcoumarin assay at pH 7.0, 30°C Sus scrofa Z-Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O assay at pH 7.0, 30°C Homo sapiens z-Gly-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
POP
-
 Homo sapiens
POP
-
 Sus scrofa
prolyl oligopeptidase
-
 Homo sapiens
prolyl oligopeptidase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens
30
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens
7
-
 assay at Sus scrofa

General Information

General Information Comment Organism
physiological function implicated in neurodegeneration and in modulation of the inflammatory response Homo sapiens