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Literature summary for 3.4.21.26 extracted from

  • Kanai, K.; Aranyi, P.; Boecskei, Z.; Ferenczy, G.; Harmat, V.; Simon, K.; Batori, S.; Naray-Szabo, G.; Hermecz, I.
    Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules (2008), J. Med. Chem., 51, 7514-7522.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2S)-1-(4-phenylbutanoyl)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
-
Sus scrofa
(2S)-1-octanoyl-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
-
Sus scrofa
(4R)-3-octanoyl-4-(pyrrolidin-1-ylcarbonyl)-1,3-thiazolidine
-
Sus scrofa
1-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-3-phenylquinoxalin-2(1H)-one
-
Sus scrofa
1-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-3-phenylquinoxalin-2(1H)-one
-
Sus scrofa
2-(3-[(2S)-4,4-difluoro-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]-3-oxopropyl) isoindole-1,3(2H)-dione
-
Sus scrofa
2-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-1H-isoindole-1,3(2H)-dione
-
Sus scrofa
2-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-1H-isoindole-1,3(2H)-dione
-
Sus scrofa
3-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-5,5-diphenylimidazolidine-2,4-dione
-
Sus scrofa
3-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-5,5-diphenylimidazolidine-2,4-dione
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Sus scrofa 5829
-

Organism

Organism UniProt Comment Textmining
Sus scrofa P23687
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Sus scrofa
-

Synonyms

Synonyms Comment Organism
POP
-
Sus scrofa
postproline cleaving enzyme
-
Sus scrofa
prolyl endopeptidase
-
Sus scrofa
prolyl oligopeptidase
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000081
-
-
Sus scrofa 2-(3-[(2S)-4,4-difluoro-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]-3-oxopropyl) isoindole-1,3(2H)-dione
0.00000088
-
-
Sus scrofa 1-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-3-phenylquinoxalin-2(1H)-one
0.000003
-
-
Sus scrofa 2-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-1H-isoindole-1,3(2H)-dione
0.000011
-
-
Sus scrofa (4R)-3-octanoyl-4-(pyrrolidin-1-ylcarbonyl)-1,3-thiazolidine
0.00003
-
-
Sus scrofa (2S)-1-(4-phenylbutanoyl)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
0.00004
-
-
Sus scrofa 2-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-1H-isoindole-1,3(2H)-dione
0.000041
-
-
Sus scrofa 3-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-5,5-diphenylimidazolidine-2,4-dione
0.000048
-
-
Sus scrofa (2S)-1-octanoyl-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
0.000059
-
-
Sus scrofa 1-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-3-phenylquinoxalin-2(1H)-one