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Literature summary for 3.4.21.26 extracted from
- Plant phenolics as prolyl endopeptidase inhibitors (2007), Arch. Pharm. Res., 30, 827-833.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2,3,4,6-pentagalloyl glucopyranoside | specific, noncompetitive, and strong inhibition | Homo sapiens |  |
| 1,2,3,6-tetragalloyl alloside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| 1,2,3-trigalloyl glucopyranoside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| 1,2,6-trigalloyl alloside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| 1,2,6-trigalloyl glucopyranoside | from Euphorbia helioscopia, specific, noncompetitive, and strong inhibition | Homo sapiens | |
| 1,3,6-trigalloyl alloside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| acetonyl geraniin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| bixanin | specific and noncompetitive inhibition | Homo sapiens | |
| corilagin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| elaeocarpusin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| euphorscopin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| geraniin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| ginkgolic acid | - |
Homo sapiens | |
| helioscopin B | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| helioscopinin A | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| helioscopinin B | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| jolkinin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| kinapsin-24 | - |
Homo sapiens | |
| macranganin | from Euphorbia fisheriana, specific, noncompetitive, and strong inhibition | Homo sapiens | |
| additional information | at least 3 galloyl groups are required for strong inhibition activity by Euphorbiaceae plants, poor inhibition by 1-galloyl glucopyranoside, 1,6-digalloyl glucopyranoside, 2,6-digalloyl glucopyranoside, 2-galloyl galactose, 6-galloyl-1-O-(4-gallate)-glucopyranoside, 6-galloyl-1-O-(phloroglucinol)-glucopyranoside, gallic acid, furosin, anthricin, gomisin A, tigloyl gomisin, 8-C-(glucopyranosyl)-kaempferol, 3-O-galloyl shikimate, 4-O-galloyl shikimate, 3-O-(2-galloyl-glucopyranosyl)-quercetin, quercetin-3-O-glucopyranoside, alpha-viniferin, 5-O-galloylquininc acid, and shizarin, overview | Homo sapiens | |
| N-benzyloxycarbonyl-L-prolyl-L-prolinal | i.e. Z-Pro-prolinal | Homo sapiens | |
| rugosin E | from Euphorbia supina, specific, noncompetitive, and strong inhibition | Homo sapiens | |
| staurosporine | - |
Homo sapiens | |
| supinanin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| teracatain | specific, noncompetitive, and strong inhibition | Homo sapiens | |
| Z-Pro-prolinal | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | of Alzheimer's disease patients, showing high enzyme expression levels, and healthy individuals | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-succinyl-Ala-Ala-Ala-4-nitroanilide | - |
Homo sapiens | N-succinyl-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prolyl endopeptidase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000004 | - |
1,3,6-trigalloyl alloside | - |
Homo sapiens | |
| 0.0000046 | - |
euphorscopin | - |
Homo sapiens | |
| 0.0000094 | - |
rugosin E | - |
Homo sapiens | |
| 0.0000171 | - |
geraniin | - |
Homo sapiens | |
| 0.0000184 | - |
elaeocarpusin | - |
Homo sapiens | |
| 0.0000194 | - |
1,2,6-trigalloyl glucopyranoside | - |
Homo sapiens | |
| 0.0000272 | - |
1,2,3,4,6-pentagalloyl glucopyranoside | - |
Homo sapiens | |
| 0.000074 | - |
acetonyl geraniin | - |
Homo sapiens | |
| 0.000091 | - |
supinanin | - |
Homo sapiens | |
| 0.000098 | - |
helioscopinin B | - |
Homo sapiens | |
| 0.000102 | - |
helioscopinin A | - |
Homo sapiens | |
| 0.000129 | - |
helioscopin B | - |
Homo sapiens | |
| 0.000194 | - |
1,2,6-trigalloyl glucopyranoside | - |
Homo sapiens | |
| 0.000203 | - |
1,2,6-trigalloyl alloside | - |
Homo sapiens | |
| 0.000212 | - |
corilagin | - |
Homo sapiens | |
| 0.000405 | - |
1,2,3,6-tetragalloyl alloside | - |
Homo sapiens | |
| 0.000441 | - |
macranganin | - |
Homo sapiens | |
| 0.00079 | - |
jolkinin | - |
Homo sapiens | |
| 0.001717 | - |
teracatain | - |
Homo sapiens | |
| 0.00249 | - |
1,2,3-trigalloyl glucopyranoside | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000267 | - |
- |
Homo sapiens | rugosin E | |
| 0.0000314 | - |
- |
Homo sapiens | 1,2,6-trigalloyl glucopyranoside | |
| 0.0000426 | - |
- |
Homo sapiens | macranganin | |
| 0.0000516 | - |
- |
Homo sapiens | Z-Pro-prolinal | |
| 0.00062 | - |
- |
Homo sapiens | ginkgolic acid | |
| 0.00077 | - |
- |
Homo sapiens | staurosporine | |
| 0.00114 | - |
- |
Homo sapiens | kinapsin-24 | |
| 0.0231 | - |
- |
Homo sapiens | bixanin | |
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