Application | Comment | Organism |
---|---|---|
nutrition | oral supplementation of celiac patients with postproline cutting enzymes could be a valuable method to eradicate the proline-rich T cell stimulatory epitopes from gluten proteins, the Aspergillus niger enzyme is a good candidate because it is highly resistant to acidic conditions and degradation by pepsin, found in the stomach, in contrast to other POPs | Aspergillus niger |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is completely resistant to digestion with pepsin | Aspergillus niger |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
gluten + H2O | Aspergillus niger | activity in the human host gastrointestinal tract, overview | ? | - |
? | |
gluten peptides + H2O | Aspergillus niger | activity in the human host gastrointestinal tract, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus niger | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Ala-Pro-4-nitroanilide + H2O | - |
Aspergillus niger | Ala-Ala-Pro + 4-nitroaniline | - |
? | |
gluten + H2O | - |
Aspergillus niger | ? | - |
? | |
gluten + H2O | activity in the human host gastrointestinal tract, overview | Aspergillus niger | ? | - |
? | |
gluten peptides + H2O | - |
Aspergillus niger | ? | - |
? | |
gluten peptides + H2O | activity in the human host gastrointestinal tract, overview | Aspergillus niger | ? | - |
? | |
N-carbobenzyloxy-glycyl-proline-4-methyloumarin-7-amide + H2O | - |
Aspergillus niger | N-carbobenzyloxy-glycyl-proline + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
prolyl endoprotease | - |
Aspergillus niger |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Aspergillus niger |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | 5 | - |
Aspergillus niger |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
2 | 12 | - |
Aspergillus niger |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
2 | - |
the enzyme remains stable at pH 2.0 | Aspergillus niger |