Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Factor VIIIa | - |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D47G | factor IXaAL, causes lower rates of factor X activation, Asp47 and the cleavage of Arg145-Ala146 are important structural features required for specific, high affinity factor IXa binding to platelets in the presence of factors VIIIa and factor X | Homo sapiens |
R145H | factor IXaCH, causes lower rates of factor X activation, Asp47 and the cleavage of Arg145-Ala146 are important structural features required for specific, high affinity factor IXa binding to platelets in the presence of factors VIIIa and factor X | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00008 | - |
Factor X | variant protein factor IXaAL | Homo sapiens | |
0.0001 | - |
Factor X | - |
Homo sapiens | |
0.00018 | - |
Factor X | variant protein factor IXaCH | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa | Homo sapiens | ? | - |
? | |
factor X + H2O | - |
Homo sapiens | factor Xa | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor IXaAL | variant protein, D47G | Homo sapiens |
factor IXaCH | variant protein, R145H | Homo sapiens |
factor IXaN | normal protein | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
12.3 | - |
Factor X | factor IXaAL | Homo sapiens | |
20.8 | - |
Factor X | factor IXaCH | Homo sapiens | |
31.2 | - |
Factor X | - |
Homo sapiens | |
43.9 | - |
Factor X | factor IXaAL, platelet-bound | Homo sapiens | |
44.5 | - |
Factor X | - |
Homo sapiens | |
110 | - |
Factor X | factor IXaCH , platelet-bound | Homo sapiens |