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Literature summary for 3.4.21.22 extracted from

  • Fay, P.J.; Koshibu, K.; Mastri, M.
    The A1 and the A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity (1999), J. Biol. Chem., 274, 15401-15406.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Factor VIIIa protein cofactor, consists of A1, A2, and A3-C1-C2 subunits, A2 enhances the turnover number 100fold, the A1 subunit increases the A2-dependent stimulation by 10fold Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa Homo sapiens ?
-
?
factor X + H2O
-
Homo sapiens factor Xa
-
?