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Literature summary for 3.4.21.22 extracted from
- gamma-Carboxylglutamic acid (Gla)-domainless blood coagulation factor IXa species: preparation and properties (1991), J. Biochem., 110, 990-996.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00008 | - |
Factor X | factor IXabeta', 0.1 mg/ml phospholipids, factor VIIIa in activating mixture | Bos taurus | |
| 0.00017 | - |
Factor X | factor IXabeta', 0.1 mg/ml phospholipids in activating mixture | Bos taurus | |
| 0.0006 | - |
Factor X | Gla-domainless factor IXabeta', 0.1 mg/ml phospholipids, factor VIIIa in activating mixture | Bos taurus | |
| 0.0008 | - |
Factor X | Gla-domainless factor IXabeta', 0.1 mg/ml phospholipids in activating mixture | Bos taurus | |
| 0.001 | - |
Factor X | Gla-domainless factor IXabeta' in activating mixture | Bos taurus | |
| 0.0239 | - |
Factor X | factor IXabeta' in activating mixture | Bos taurus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47000 | - |
factor IXabeta', non reducing PAGE | Bos taurus |
| 55000 | - |
factor IXaalpha, non reducing PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | Bos taurus | gamma-carboxyglutamic acid, Gla-domains of vitamin K-dependent coagulation factors are essential for binding of phospholipid and for the activation raections such as factor X, the interaction of the Gla-domain with metal ions like Ca2+ is essential for its function | ? | - |
? |  |
| factor X + H2O | Bos taurus | a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| factor IXabeta' | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | gamma-carboxyglutamic acid, Gla-domains of vitamin K-dependent coagulation factors are essential for binding of phospholipid and for the activation raections such as factor X, the interaction of the Gla-domain with metal ions like Ca2+ is essential for its function | Bos taurus | ? | - |
? | |
| factor X + H2O | a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa | Bos taurus | ? | - |
? | |
| factor X + H2O | - |
Bos taurus | factor Xa | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| blood coagulation factor IXa | - |
Bos taurus |
| factor IXaalpha | - |
Bos taurus |
| factor IXabeta | - |
Bos taurus |
| factor IXabeta' | converted from factor IXAalpha by alpha-chymotrypsin in the presence of Ca2+ | Bos taurus |
| Gla-domainless factor IXabeta' | - |
Bos taurus |
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Release 2023.1 (January 2023)
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