Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor VIII | in modified form, established in the activation of factor X | Homo sapiens | |
Phospholipid | increases the activation of factor X | Homo sapiens | |
platelet factor 3 | in vivo, established in the activation of factor X | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombin III | a nonspecific protein inhibitor, in presence of heparin, this forms a stable or covalent-like intermediate with the factor IXa | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | factor IX activation is the first calcium-dependent reaction in intrinsic system clotting | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
endothelium | factor IXa binds specifically to the surface of endothelial cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa | Homo sapiens | ? | - |
? | |
factor X + H2O | - |
Homo sapiens | factor Xa | activated form | ? |